This study presents the determinants of childhood stunting as the consequence of child malnutrition. We checked two groups of factors-the socio-economic situation and climate vulnerability-using disaggregated sub-regional data in the spatial context. Data related to the percentage of stunted children in Pakistan for 2017 were retrieved from MICS 2017-18 along with other features. We used three quantitative models: ordinary least squares regression (OLS) to examine the linear relationships among the selected features, spatial regression (SDEM) to identify and capture the spatial spillover effect, and the Extreme Gradient Boosting machine learning algorithm (XGBoost) to analyse the importance of spatial lag and generate predictions. The results showed a high degree of spatial clustering in childhood stunting at the sub-regional level. We found that a 1 percentage point (p.p.) increase in multi-dimensional poverty may translate into a 0.18 p.p. increase in childhood stunting. Furthermore, high climate vulnerability and common marriages before age 15 each exacerbated childhood stunting by another 1 p.p. On the contrary, high female literacy and their high exposure to mass media, together with low climate vulnerability, may reduce childhood stunting. Model diagnostics showed that the SDEM outperformed the OLS model, as AIC = 766 > AIC = 760. Furthermore, XGBoost generated the most accurate predictions in comparison to OLS and SDEM, having the lowest root-mean-square error (RMSE).
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http://dx.doi.org/10.3390/ijerph191710967 | DOI Listing |
Pediatr Pulmonol
January 2025
Department of Clinical Research, Faculty of Health sciences, University of Southern Denmark, Odense, Denmark.
Introduction: A main feature of CDH is lung hypoplasia and the related presentation of pulmonary hypertension and cardiac dysfunction. Multiple factors influence pulmonary status after CDH: degree of hypoplasia, ventilator-induced injury, altered growth and development of pulmonary structures, reduced diaphragm function and chest wall abnormalities. The evolution of pulmonary sequela in this population is still unclear.
View Article and Find Full Text PDFJBMR Plus
February 2025
Division of Biosciences, College of Dentistry, The Ohio State University, Columbus, OH, 43210, United States.
Hypophosphatasia (HPP) is an inherited error in metabolism resulting from loss-of-function variants in the gene, which encodes tissue-nonspecific alkaline phosphatase (TNAP). TNAP plays a crucial role in biomineralization of bones and teeth, in part by reducing levels of inorganic pyrophosphate (PP), an inhibitor of biomineralization. HPP onset in childhood contributes to rickets, including growth plate defects and impaired growth.
View Article and Find Full Text PDFInt J Mol Sci
January 2025
National Neuroscience Institute, 11 Jalan Tan Tock Seng, Singapore 308433, Singapore.
Alzheimer's disease (AD) is characterised by progressive neurodegeneration with the formation of amyloid beta (Aβ) plaques and neurofibrillary tau tangles in the brain parenchyma. The causes of AD have been attributed to a combination of age-related changes within the brain as well as genetic, environmental and lifestyle factors. However, a recent study by Banerjee et al.
View Article and Find Full Text PDFGenes (Basel)
January 2025
Fondazione IRCSS Ca' Granda Ospedale Maggiore Policlinico, 20122 Milano, Italy.
Mendelian disorders of the epigenetic machinery (MDEMs) include a large number of conditions caused by defective activity of a member of the epigenetic machinery. MDEMs are characterized by multiple congenital abnormalities, intellectual disability and abnormal growth. that can be variably up- or down-regulated.
View Article and Find Full Text PDFInt J Environ Res Public Health
January 2025
Center for Community-Engaged Medicine, Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA 02111, USA.
We report the results of a scoping review of the literature investigating associations between positive childhood experiences (PCEs) and selected health outcomes to identify which have the highest level of research activity based on the indexed academic literature. Yielded articles underwent title/abstract (Ti/Ab) and full text screening utilizing inclusion/exclusion criteria. The review was guided by PCE categories from the Healthy Outcomes from Positive Experiences framework: relationships, environment, engagement, and emotional growth.
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