AI Article Synopsis
- Cancer remains a significant global health issue, with some patients not responding well to traditional treatments and facing poor outcomes.
- Immunotherapy, particularly the use of recombinant antibodies like single-chain fragment variable (scFv), is an emerging strategy that targets tumor cells effectively.
- The review highlights recent advancements in scFvs as diagnostic and therapeutic tools, focusing on preclinical developments and their future potential in clinical trials.
Article Abstract
Cancer remains a public health problem worldwide. Although conventional therapies have led to some excellent outcomes, some patients fail to respond to treatment, they have few therapeutic alternatives and a poor survival prognosis. Several strategies have been proposed to overcome this issue. The most recent approach is immunotherapy, particularly the use of recombinant antibodies and their derivatives, such as the single-chain fragment variable (scFv) containing the complete antigen-binding domains of a whole antibody that successfully targets tumor cells. This review describes the recent progress made with scFvs as a cancer diagnostic and therapeutic tool, with an emphasis on preclinical approaches and their potential use in clinical trials.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9455005 | PMC |
| http://dx.doi.org/10.3390/cancers14174206 | DOI Listing |
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