AI Article Synopsis
- The study compares endothelial injury in children with Kawasaki Disease (KD), Multisystem Inflammatory Syndrome in Children (MIS-C), and acute COVID-19 (AC19) by measuring circulating endothelial cells (CECs).
- Results showed higher levels of CECs in KD and AC19 patients compared to those with MIS-C, with KD patients showing an increase in CECs from acute to subacute stages.
- The findings suggest that CECs may serve as biomarkers of inflammation and endothelial dysfunction in KD and MIS-C, indicating different mechanisms of vascular injury in these conditions, warranting further research.
Article Abstract
Background: Kawasaki Disease (KD) and Multisystem Inflammatory Syndrome in Children (MIS-C) are pediatric diseases characterized by systemic inflammation and vascular injury, potentially leading to coronary artery lesions (CALs). Data on vascular injury occurring during acute COVID-19 (AC19) in children are still lacking. The aim of our study was to investigate endothelial injury in KD-, MIS-C- and AC19-dosing circulating endothelial cells (CECs).
Methods: We conducted a multicenter prospective study. CECs were enumerated by CellSearch technology through the immunomagnetic capture of CD146-positive cells from whole blood.
Results: We enrolled 9 KD, 20 MIS-C and 10 AC19. During the acute stage, the AC19 and KD patients had higher CECs levels than the MIS-C patients. From the acute to subacute phase, a significant CEC increase was observed in the KD patients, while a mild decrease was detected in the MIS-C patients. Cellular clusters/syncytia were more common in the KD patients. No correlation between CECs and CALs were found in the MIS-C patients. The incidence of CALs in the KD group was too low to investigate this correlation.
Conclusions: Our study suggests a possible role of CECs as biomarkers of systemic inflammation and endothelial dysfunction in KD and MIS-C and different mechanisms of vascular injury in these diseases. Further larger studies are needed.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9456219 | PMC |
| http://dx.doi.org/10.3390/ijms231710106 | DOI Listing |
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