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Clinical Images: Groove sign: heeding clue to eosinophilic fasciitis.
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Tuberk Toraks
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Department of Radiology, Tokat Gaziosmanpasa University Faculty of Medicine, Tokat, Türkiye.
Introduction: Diffuse pulmonary ossification (DPO) refers to the unusual formation of mature bone tissue within the lung parenchyma. It has been shown to be associated with a number of cardiac and chronic lung diseases. The relation between DPO and idiopathic pulmonary fibrosis (IPF) has been shown in the literature.
View Article and Find Full Text PDFAcute Aortic Dissection Masquerading as Acute Coronary Syndrome: Is Echocardiogram Mandatory before Primary Percutaneous Coronary Intervention?
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Dr Md Azizul Hasan Khandaker, Acting Senior Specialist, Department of Cardiology, National Heart Center, Royal Hospital, Muscat, Sultanate of Oman; E-mail:
A 58-year-old hypertensive man was admitted with severe central chest pain and palpitation. His electrocardiogram (ECG) showed fast atrial fibrillation with features suggestive of left main coronary artery occlusion. He was taken to the Cath-lab but surprisingly, coronary angiogram (CAG) showed no stenosis.
View Article and Find Full Text PDFImaging phenotype reveals that disulfirams induce protein insolubility in the mitochondrial matrix.
Sci Rep
December 2024
Center for Drug Discovery, Graduate School of Pharmaceutical Sciences, University of Shizuoka, Suruga-ku, Shizuoka, 422-8526, Shizuoka, Japan.
The cell painting assay is useful for understanding cellular phenotypic changes and drug effects. To identify other aspects of well-known chemicals, we screened 258 compounds with the cell painting assay and focused on a mitochondrial punctate phenotype seen with disulfiram. To elucidate the reason for this punctate phenotype, we looked for clues by examining staining steps and gene knockdown as well as examining protein solubility and comparing cell lines.
View Article and Find Full Text PDFMultiphasic Computed Tomography Enhancement Characteristics and Utility of Delayed Phase in Infiltrative Hepatocellular Carcinoma.
Indian J Radiol Imaging
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Department of Hepatology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
The aims of this study are to compare the multiphasic contrast-enhanced computed tomography (CECT) characteristics of infiltrative hepatocellular carcinoma (HCC) with nodular HCC and to assess the conspicuity of infiltrative HCC on different phases of CECT. This retrospective study comprised consecutive treatment-naive cirrhotic patients diagnosed with infiltrative and nodular HCC between January 2020 and December 2021 based on a multiphasic CECT (comprising arterial, portal venous, and delayed phases). The diagnosis of HCC was based on the Liver Imaging Reporting and Data System (LI-RADS) v2018 criteria (LR-4 and LR-5 lesions).
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