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PROTACs in the treatment of viral diseases.
Future Med Chem
January 2025
Department of Pharmacognosy, Goa College of Pharmacy, Goa University, Panaji, India.
The vascular effects of peppermint ( L) on aorta in a mouse model: an and computational study.
J Biomol Struct Dyn
December 2024
Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
The present study examined the vascular effects of peppermint or mint () using an abdominal aortic rings model. Concentration-response curves for mint oil were generated after precontracting isolated mouse aorta with phenylephrine. The effect of different receptor antagonists and ion channel or enzyme inhibitors on the vasorelaxant potential of mint oil were studied.
View Article and Find Full Text PDFNitric Oxide and Small and Intermediate Calcium-Activated Potassium Channels Mediate the Vasodilation Induced by Apigenin in the Resistance Vessels of Hypertensive Rats.
Molecules
November 2024
Laboratory of Cardiometabolic Pharmacology, Postgraduate Program in Pharmacology (UFPR), Federal University of Paraná, Curitiba 81531-980, PR, Brazil.
Article Synopsis
- Apigenin, a flavonoid thought to benefit cardiovascular health, was studied for its effects on vascular function in Spontaneously Hypertensive Rats (SHRs) to understand its mechanisms of action.
- Vascular beds from SHRs were tested with varying doses of apigenin, showing that its ability to lower blood pressure depended on the presence of endothelial cells and was significantly reduced by inhibitors of nitric oxide and potassium channels.
- The research concluded that apigenin causes vasodilation primarily through endothelial nitric oxide and calcium-activated potassium channels, suggesting its potential for therapeutic use in cardiovascular diseases and the need for more clinical studies.
[Protective effect of soy proteins under excessive amount of fats in the diet of rats].
Vopr Pitan
November 2024
Pavlov Institute of Physiology, Russian Academy of Sciences, 199034, Saint Petersburg, Russian Federation.
Excessive fat intake causes the development of metabolic syndrome (MS). Our studies have shown that soy proteins in the diet improve vascular reactivity in rats with a high-salt dietary load and renal dysfunction. We hypothesized that the introduction of soy proteins into a high-fat diet (HFD) can prevent or reduce vascular dysfunction.
View Article and Find Full Text PDFA potent dual inhibitor targeting COX-2 and HDAC of acute myeloid leukemia cells.
Mol Divers
October 2024
Department of Radiology, Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province, The Affiliated Hospital of Southwest Medical University, Luzhou, 646000, China.
Acute myeloid leukemia (AML) is an aggressive cancer with complex issues of drug resistance and a poor prognosis; thus, effective therapeutics is urgently needed for AML. In this study, we designed and synthesized dual cyclooxygenase-2 (COX-2) and histone deacetylase (HDAC) inhibitors, IMC-HA and IMC-OPD, and applied them for the treatment of AML. IMC-HA comprised a COX-2 inhibitor skeleton of indomethacin (IMC) and an HDAC inhibitor moiety of the hydroxamic group and was found to exhibit potent antiproliferative activity against AML cells (THP-1 and U937) and low cytotoxicity toward normal cells.
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