AI Article Synopsis
- Trypanosomatid protozoa are unique parasites that have developed special ways to manage their life cycles and adapt to various hosts, differing from typical models.
- Understanding their adaptation strategies could lead to better drug control methods.
- The review emphasizes the role of protein kinases in these organisms, comparing the distinct features of trypanosomatid kinomes with other eukaryotes and focusing on Leishmania and African trypanosomes.
Article Abstract
Trypanosomatid parasitic protozoa are divergent from opisthokont models and have evolved unique mechanisms to regulate their complex life cycles and to adapt to a range of hosts. Understanding how these organisms respond, adapt, and persist in their different hosts could reveal optimal drug-control strategies. Protein kinases are fundamental to many biological processes such as cell cycle control, adaptation to stress, and cellular differentiation. Therefore, we have focused this review on the features and functions of protein kinases that distinguish trypanosomatid kinomes from other eukaryotes. We describe the latest research, highlighting similarities and differences between two groups of trypanosomatid parasites, Leishmania and African trypanosomes.
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| http://dx.doi.org/10.1016/j.pt.2022.08.009 | DOI Listing |
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