Air pollutants, especially ambient particulate matter (PM), detrimentally impact human health and cause premature deaths. The dynamic characteristics and associated health risks of PM are analyzed based on the standard deviational ellipse (SDE) and trend analysis in Saudi Arabia (SAU) from 1998 to 2018 by utilizing recently updated satellite-derived PM concentrations (V4.GL.03). The outcomes show that the national average PM concentration increased from 28 μg/m to 45 μg/m with a growth rate of 2.3 μg/m/year. The center of median PM concentrations moved to the southeast over the years studied due to the presence of vast sandy deserts, sand dunes, a busy port, and coastal and industrial areas in this region. The areas of SAU that experienced PM concentrations above 35 μg/m increased from 20% to 70%. The rapid-fast growth (RFG) class acquired from the unsupervised classification has the fastest growth rate of 2.5 μg/m/yr, occurring in southeastern SAU, namely Ash-Sharqiyah, Ar-Riyad, and Najran. It covered ∼27% of the total area of SAU over the study period. Whereas, the slow growth (SG) class with a less than 0.2 μg/m/yr growth rate covered 12% of the total area of SAU, distributed in northwestern regions. The extent of extremely-high risk areas corresponding to greater than 1 × 10 μg·person/m increased from 4% to 11%, particularly in Makkah, Central Al-Madinah, and western Asir, Jizan, mid-eastern Najran, Al-Quassim, and mid-eastern Ar-Riyad and Ash Sharqiyah.
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http://dx.doi.org/10.1016/j.chemosphere.2022.136296 | DOI Listing |
J Osteopath Med
January 2025
Arizona College of Osteopathic Medicine, Midwestern University, Glendale, AZ, USA.
Context: Point-of-care ultrasound (POCUS) has diverse applications across various clinical specialties, serving as an adjunct to clinical findings and as a tool for increasing the quality of patient care. Owing to its multifunctionality, a growing number of medical schools are increasingly incorporating POCUS training into their curriculum, some offering hands-on training during the first 2 years of didactics and others utilizing a longitudinal exposure model integrated into all 4 years of medical school education. Midwestern University Arizona College of Osteopathic Medicine (MWU-AZCOM) adopted a 4-year longitudinal approach to include POCUS education in 2017.
View Article and Find Full Text PDFPharm Dev Technol
January 2025
Department of Pharmacy, School of Chemistry and Chemical Engineering, Liaoning Normal University, Dalian 116029, China.
In this paper, the pH-sensitive targeting functional material NGR-poly(2-ethyl-2-oxazoline)-cholesteryl methyl carbonate (NGR-PEtOz-CHMC, NPC) modified quercetin (QUE) liposomes (NPC-QUE-L) was constructed. The structure of NPC was confirmed by infrared spectroscopy (IR) and nuclear magnetic resonance hydrogen spectrum (H-NMR). Pharmacokinetic results showed that the accumulation of QUE in plasma of the NPC-QUE-L group was 1.
View Article and Find Full Text PDFNMR Biomed
February 2025
Department of Biomedical Engineering, Yale University, New Haven, Connecticut, USA.
Cellular metabolism is inextricably linked to transmembrane levels of proton (H), sodium (Na), and potassium (K) ions. Although reduced sodium-potassium pump (Na-K ATPase) activity in tumors directly disturbs transmembrane Na and K levels, this dysfunction is a result of upregulated aerobic glycolysis generating excessive cytosolic H (and lactate) which are extruded to acidify the interstitial space. These oncogene-directed metabolic changes, affecting intracellular Na and H, can be further exacerbated by upregulation of ion exchangers/transporters.
View Article and Find Full Text PDFExplor Target Antitumor Ther
November 2024
Oncology Institute of Southern Switzerland (IOSI), Ente Ospedaliero Cantonale (EOC), 6500 Bellinzona, Switzerland.
Advanced urothelial carcinoma (aUC) has a dismal prognosis, with a 5-year survival rate of approximately 10%. Platinum-based chemotherapy has been the backbone of the first-line treatment of aUC for over 40 years. Only in the last decade, the treatment of aUC has evolved and been enriched with new classes of drugs that demonstrated pivotal improvements in terms of oncological responses and, ultimately, survival.
View Article and Find Full Text PDFCureus
December 2024
Otolaryngology, Yokosuka Kyosai Hospital, Yokosuka, JPN.
Objective We evaluated the outcomes of tympanic membrane regenerative treatment using gelatin sponge, recombinant basic fibroblast growth factor (bFGF), and fibrin glue at Yokosuka Kyosai Hospital. Methodology We enrolled a total of 42 patients with tympanic membrane perforations (TMPs) (44 ears; right:left = 21:23) that were treated using gelatin sponge, recombinant bFGF, and fibrin glue between July 2020 and December 2023 at Yokosuka Kyosai Hospital. TMP closure rates, improvement of hearing level, and complications were retrospectively included in the evaluation items.
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