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Brain health: Pathway to primary prevention of neurodegenerative disorders of environmental origin.
J Neurol Sci
December 2024
Graduate School of International Development, Nagoya University, Nagoya, Japan.
While rising global rates of neurodegenerative disease encourage early diagnosis and therapeutic intervention to block clinical expression (secondary prevention), a more powerful approach is to identify and remove environmental factors that trigger long-latencybrain disease (primary prevention) by acting on a susceptible genotype or acting alone. The latter is illustrated by the post-World War II decline and disappearance of Amyotrophic Lateral Sclerosis and Parkinsonism-Dementia Complex (ALS/PDC), a prototypical often-familial neurodegenerative disease formerly present in very high incidence on the island of Guam. Lessons learned from 75 years of investigation on the etiology of ALS/PDC include: the importance of focusing field research on the disease epicenter and patients with early-onset disease; soliciting exposure history from patients, family, and community to guide multidisciplinary biomedical investigation; recognition that disease phenotype may vary with exposure history, and that familial brain disease may have a primarily environmental origin.
View Article and Find Full Text PDFA Review of COVID-19 Hotels in New York City During the Early 2020 Outbreak: An Alternative Care Model.
Cureus
July 2024
Population and Public Health Sciences, University of Southern California Keck School of Medicine, Los Angeles, USA.
New York City (NYC) was the epicenter of the early US COVID-19 pandemic. From March to May 2020, overburdened healthcare centers precipitated an emergent need for non-traditional facilities to meet patient care demands. Given travel restrictions and NYC's underutilized tourist infrastructure, hotels were available to support emergency response needs.
View Article and Find Full Text PDFCOVID-19 in nursing homes: Geographic diffusion and regional risk factors from January 1 to July 26, 2020 of the pandemic.
PLoS One
August 2024
Department of Geography, Environment, and Spatial Sciences, Michigan State University, East Lansing, Michigan, United States of America.
Background: COVID-19 deaths in nursing homes accounted for 30.2% of all COVID-19 deaths in the United States during the early weeks (1-January to 26-July, 2020) of the pandemic. This study presents the geographic diffusion of COVID-19 cases and deaths in nursing homes during this time period, while also providing explanation of regional risk factors.
View Article and Find Full Text PDFThe Lagos State COVID-19 Think-tank, a Potential Framework for Decision-making in a Pandemic Era.
Ann Afr Med
July 2024
Lagos State COVID-19 Think-Tank Committee, Lagos Sate Ministry of Heath, Alausa, Nigeria.
Lagos state remains the epicenter of COVID-19 infection in Nigeria. To facilitate the emergency preparedness and response to COVID-19, the State Governor and Incident Commander constituted a Think Tank comprising 13 experts from various disciplines committed to the health of the public. The Think Tank assisted the government with decision-making strategies and supported the emergency operation centre (EOC) for the COVID-19 response.
View Article and Find Full Text PDFEffects of the COVID-19 Pandemic on Everyday Neurosurgical Practice in Alsace, France: Lessons Learned, Current Perspectives, and Future Challenges-Preliminary Results of a Longitudinal Multicentric Study Registry.
Medicina (Kaunas)
February 2024
Neurosurgery Department, Strasbourg University Hospital, 67000 Strasbourg, France.
: The global outbreak caused by the SARS-CoV-2 pandemic disrupted healthcare worldwide, impacting the organization of intensive care units and surgical care units. This study aimed to document the daily neurosurgical activity in Alsace, France, one of the European epicenters of the pandemic, and provide evidence of the adaptive strategies deployed during such a critical time for healthcare services. : The multicentric longitudinal study was based on a prospective cohort of patients requiring neurosurgical care in the Neurosurgical Departments of Alsace, France, between March 2020 and March 2022.
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