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Type 1 VWD classification revisited: novel insights from combined analysis of the LoVIC and WiN studies.
Blood
April 2024
Irish Centre for Vascular Biology, School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland, Dublin, Ireland.
Article Synopsis
- There is ongoing debate about the definition of type 1 von Willebrand disease (VWD), with previous guidelines suggesting that VWF levels <30 IU/dL indicate type 1 VWD and levels between 30 to 50 IU/dL signify low VWF.
- A study combining data from two national cohorts found that while nearly half of type 1 VWD patients had VWF levels <30 IU/dL, a significant number showed increases to low or normal levels with age.
- The analysis indicates that low VWF is not a separate condition but part of the evolving phenotype of age-dependent type 1 VWD, suggesting a need to reconsider current classification criteria for the disease.
Rapid exacerbation of lymphocytic infundibuloneurohypophysitis.
Medicine (Baltimore)
March 2017
Department of Diabetes, Endocrinology and Nutrition, Graduate School of Medicine, Kyoto University, Kawahara-cho, Shogoin, Sakyo-ku, Kyoto, Japan Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, Nagoya, Japan. Department of Neurosurgery, Graduate School of Medicine, Kyoto University, Kawahara-cho, Shogoin, Sakyo-ku, Kyoto, Japan.
Rationale: Lymphocytic hypophysitis is a relatively rare autoimmune disease defined by lymphocytic infiltration to the pituitary. Its rarity and wide spectrum of clinical manifestations make clarification of the pathology difficult. Here, we describe a case we examined from the primary diagnosis to final discharge, showing the serial progression of lymphocytic infundibuloneurohypophysitis (LINH) to panhypopituitarism with extrapituitary inflammatory invasion in a short period, and responding favorably to high-dose glucocorticoid treatment.
View Article and Find Full Text PDFRevisiting transfusion safety and alternatives to transfusion.
Presse Med
February 2017
Lausanne University Hospital CHUV, Department of Anesthesiology, rue du Bugnon 21, 1011 Lausanne, Switzerland.
Transfusion of blood products can be life saving when used appropriately. It carries however at the same time a potential for morbidity and mortality, depending on the patient, the product or the setting. Numerous strategies have been elaborated to minimize these risks, and in recent years, transfusion has no longer been regarded as essential for the management of a wide range of diseases.
View Article and Find Full Text PDFCyclophosphamide and water retention: mechanism revisited.
J Pediatr Endocrinol Metab
June 2000
Division of Endocrinology, Hospital for Sick Children, Toronto, Ontario, Canada.
We describe an 8 year-old girl with established diabetes insipidus who developed cyclophosphamide-associated antidiuresis. The patient had received cyclophosphamide as part of a high-dose chemotherapy regimen for recurrent suprasellar dysgerminoma prior to autologous bone marrow transplantation. Urinary output decreased and specific gravity increased shortly after a 1 hour i.
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