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Supportive treatment to chemotherapy with MMC, in patients with ocular surface squamous neoplasia or conjunctival melanocytic tumor. | LitMetric

AI Article Synopsis

  • The study aimed to evaluate the effectiveness of hyaluronic acid eye drops as supportive therapy in patients with ocular surface neoplasia undergoing treatment with mitomycin C (MMC).
  • Researchers analyzed 35 patients, focusing on improvements in eye health through both subjective and objective measures over a six-month period.
  • Results indicated that hyaluronic acid therapy significantly improved ocular surface integrity, with lactobionic acid-conjugated drops showing similar benefits and potential for better subjective outcomes.

Article Abstract

Purpose: Since there is a lack of clear information regarding the benefit to combine supportive therapies (such as artificial tears) to mitomycin C (MMC) in the treatment of ocular surface neoplasia, the primary purpose of the study was to evaluate hyaluronic acid eye drops and hyaluronic acid-conjugated lactobionic acid (LACTOyal FREE) eye drops as supportive therapy.

Methods: Retrospective evaluation of patients with ocular surface squamous neoplasia or conjunctival melanocytic tumor treated with MMC, who had used also artificial tears as supportive treatment. A 6-month follow-up with evaluation of subjective and objective tests for ocular surface integrity was conducted.

Results: A total of 35 patients were analyzed, most of them with squamous disease (71.4%). The break-up time (BUT), Ocular Surface Disease Index (OSDI) and Schirmer test values showed a significant difference at any time point with overall population. No statistical difference was found among subgroups (Lactoyal vs No Lactoyal).

Conclusion: The use of an ancillary therapy based on hyaluronic acid allows to improve both subjective and objective ocular parameters, reducing MMC induced adverse effects. Meantime, hyaluronic acid-conjugated lactobionic acid eye drops highlighted the same advantages with a more positive trend in OSDI results.

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Source
http://dx.doi.org/10.1007/s00432-022-04241-5DOI Listing

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