Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9457678 | PMC |
| http://dx.doi.org/10.7554/eLife.83258 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Adult-born granule cells improve stimulus encoding and discrimination in the dentate gyrus.
Elife
August 2023
Instituto de Investigacion en Biomedicina de Buenos Aires (IBioBA) - CONICET/Partner Institute of the Max Planck Society, Polo Cientifico Tecnologico, Buenos Aires, Argentina.
Heterogeneity plays an important role in diversifying neural responses to support brain function. Adult neurogenesis provides the dentate gyrus with a heterogeneous population of granule cells (GCs) that were born and developed their properties at different times. Immature GCs have distinct intrinsic and synaptic properties than mature GCs and are needed for correct encoding and discrimination in spatial tasks.
View Article and Find Full Text PDFExposure to elevated doses of ionizing radiation, such as those in therapeutic procedures, catastrophic accidents, or space exploration, increases the risk of cognitive dysfunction. The full range of radiation-induced cognitive deficits is unknown, partly because commonly used tests may be insufficiently sensitive or may not be adequately tuned for assessing the fine behavioral features affected by radiation. Here, we asked whether γ-radiation might affect learning, memory, and the overall ability to adapt behavior to cope with a challenging environment (cognitive/behavioral flexibility).
View Article and Find Full Text PDFAdult-born neurons maintain hippocampal cholinergic inputs and support working memory during aging.
Mol Psychiatry
December 2023
Department of Psychiatry, Columbia University, New York, NY, 10032, USA.
Adult neurogenesis is reduced during aging and impaired in disorders of stress, memory, and cognition though its normal function remains unclear. Moreover, a systems level understanding of how a small number of young hippocampal neurons could dramatically influence brain function is lacking. We examined whether adult neurogenesis sustains hippocampal connections cumulatively across the life span.
View Article and Find Full Text PDFAdult neurogenesis is reduced during aging and impaired in disorders of stress, memory, and cognition though its normal function remains unclear. Moreover, a systems level understanding of how a small number of young hippocampal neurons could dramatically influence brain function is lacking. We examined whether adult neurogenesis sustains hippocampal connections cumulatively across the life span.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!