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| http://dx.doi.org/10.1002/wps.21016 | DOI Listing |
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The use of 7T MRI in multiple sclerosis: review and consensus statement from the North American Imaging in Multiple Sclerosis Cooperative.
Brain Commun
October 2024
Radiology, Pathology and Laboratory Medicine, Physics and Astronomy, International Collaboration on Repair Discoveries, University of British Columbia, Vancouver, Canada, BC V6T 1Z4.
The use of ultra-high-field 7-Tesla (7T) MRI in multiple sclerosis (MS) research has grown significantly over the past two decades. With recent regulatory approvals of 7T scanners for clinical use in 2017 and 2020, the use of this technology for routine care is poised to continue to increase in the coming years. In this context, the North American Imaging in MS Cooperative (NAIMS) convened a workshop in February 2023 to review the previous and current use of 7T technology for MS research and potential future research and clinical applications.
View Article and Find Full Text PDFPooled analysis of multiple sclerosis findings on multisite 7 Tesla MRI: Protocol and initial observations.
Hum Brain Mapp
August 2024
Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Although 7 T MRI research has contributed much to our understanding of multiple sclerosis (MS) pathology, most prior data has come from small, single-center studies with varying methods. In order to truly know if such findings have widespread applicability, multicenter methods and studies are needed. To address this, members of the North American Imaging in MS (NAIMS) Cooperative worked together to create a multicenter collaborative study of 7 T MRI in MS.
View Article and Find Full Text PDFClinical trials for progressive multiple sclerosis: progress, new lessons learned, and remaining challenges.
Lancet Neurol
March 2024
Mellen Center for Multiple Sclerosis, Neurological Institute, Cleveland Clinic, Cleveland, OH, USA.
Despite the success of disease-modifying treatments in relapsing multiple sclerosis, for many individuals living with multiple sclerosis, progressive disability continues to accrue. How to interrupt the complex pathological processes underlying progression remains a daunting and ongoing challenge. Since 2014, several immunomodulatory approaches that have modest but clinically meaningful effects have been approved for the management of progressive multiple sclerosis, primarily for people who have active inflammatory disease.
View Article and Find Full Text PDFA Chromo-fluorogenic Probe for Selective Detection of Picric Acid Alongside Its Recovery by Aliphatic Amines and Construction of Molecular Logic Gates.
J Fluoresc
December 2023
Department of Chemistry, University of North Bengal, Raja Rammohunpur, Darjeeling, West Bengal, 734013, India.
Nitroaromatic compounds are illicit explosive chemicals. For environmental security and homeland safety, selective and sensitive identification of these secondary-class explosives has been a reason for the exhaustive research arena of chemists for about a decade. We introduced a sensitive optical sensor with desalted neutral red (NR) dye.
View Article and Find Full Text PDFDysregulation of RNA modification systems in clinical populations with neurocognitive disorders.
Neural Regen Res
June 2024
Division of Cells, Organisms and Molecular Genetics, School of Life Sciences, University of Nottingham, Nottingham, UK.
The study of modified RNA known as epitranscriptomics has become increasingly relevant in our understanding of disease-modifying mechanisms. Methylation of N6 adenosine (m6A) and C5 cytosine (m5C) bases occur on mRNAs, tRNA, mt-tRNA, and rRNA species as well as non-coding RNAs. With emerging knowledge of RNA binding proteins that act as writer, reader, and eraser effector proteins, comes a new understanding of physiological processes controlled by these systems.
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