AI Article Synopsis
- A 60-year-old man undergoing treatment for metastatic melanoma with Ipilimumab and Nivolumab developed severe eye issues, specifically bilateral peripheral ulcerative keratitis, which led to corneal perforation.
- Initial symptoms included a foreign body sensation and tearing, but traditional anti-inflammatory treatments failed, necessitating further surgical interventions.
- The case highlights how immune checkpoint inhibitors can disrupt corneal immunity, resulting in serious autoimmune complications in the eyes.
Article Abstract
Purpose: To present a case of immune checkpoint inhibitor-induced bilateral peripheral ulcerative keratitis that progressed to corneal perforation requiring keratoplasty in both eyes.
Observations: We describe the course of a 60-year-old man treated with a combination of Ipilimumab and Nivolumab for metastatic melanoma who presented with foreign body sensation and epiphora in both eyes.Bilateral immune-related peripheral ulcerative keratitis was refractory to topical anti-inflammatory therapy, necessitating repetitive, but unsuccessful cyanoacrylate gluing procedure followed by bilateral lamellar mini-keratoplasty.
Conclusions And Importance: Combined immune checkpoint inhibition revokes the corneal immune privilege and can lead to auto-immune keratitis with recalcitrant progression to ulceration and perforation.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9442328 | PMC |
| http://dx.doi.org/10.1016/j.ajoc.2022.101686 | DOI Listing |
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