AI Article Synopsis
- - Radiofrequency ablation (RFA) is an effective treatment for Barrett's esophagus (BE) neoplasia, but it often leads to significant post-procedural pain and dysphagia in patients, with pain reported in 95% of cases lasting for about 14 days.
- - The severity and duration of post-RFA pain are influenced by factors such as the length of BE, the patient's age, and whether they have undergone prior ablation, while dysphagia occurs in 83% of cases, usually lasting around 13 days.
- - The study highlights the importance of considering these post-procedural symptoms when discussing treatment options with patients, as RFA can impose a considerable burden on their well
Article Abstract
Background: Radiofrequency ablation (RFA) is effective for eradication of Barrett's esophagus (BE) neoplasia, but little is known on the course of pain and dysphagia after RFA. We aimed to describe the course of post-RFA symptoms and to identify possible associated risk factors.
Methods: In this multicenter, observational cohort study, all RFA procedures registered in a prospective database were included. Patient and treatment characteristics were collected from medical records and patients self-registered post-procedural symptoms in electronic symptom diaries for 14 days. Mixed model regression was used for the analyses.
Results: In total, 255 diaries were completed. Post-RFA pain was reported for 95 % (95 %CI 93-98) of procedures (median duration 14 days; 25th-75th percentiles [p25-p75] 11-14) and major pain for 64 % (95 %CI 58-69; median duration 8 days, p25-p75 3-13). Post-procedural pain significantly increased with BE length, younger age, and no prior ablation. Dysphagia was present after 83 % (95 %CI 79-88) of procedures (median duration 13 days, p25-p75 9-14). The risk of dysphagia decreased with age and increased when patients experienced more pain.
Conclusions: RFA treatment for BE-related neoplasia seems a significant burden for patients, and post-procedural symptoms should be taken into account when counseling patients before starting endoscopic eradication therapy.
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| http://dx.doi.org/10.1055/a-1929-1448 | DOI Listing |
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