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| http://dx.doi.org/10.1186/s12943-022-01614-9 | DOI Listing |
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Hypoalbuminemia and cisplatin-induced acute kidney injury.
Front Pharmacol
December 2024
Department of Pharmacy, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
Background: Cisplatin binds to serum albumin in the body at a rate of 90%, and high levels of free cisplatin are a significant cause of its nephrotoxicity. Therefore, hypoalbuminemia theoretically poses a significant risk factor for cisplatin-induced acute kidney injury (CIA) and can be easily corrected. However, existing research results are inconsistent.
View Article and Find Full Text PDFEffect of Hydration with Bicarbonate Ringer's Solution on Cisplatin-Induced Acute Kidney Injury in Patients with Esophageal Cancer: A Retrospective Cohort Study.
Oncology
January 2025
Department of Pharmacy, Osaka University Hospital, Suita, Japan.
Article Synopsis
- Cisplatin (CDDP) is known to cause acute kidney injury (AKI), and magnesium supplementation may help prevent this side effect; sodium bicarbonate Ringer's solution (BRS), which contains magnesium, was studied for its effectiveness compared to normal saline in CDDP treatment.
- In a study of 131 patients treated for esophageal cancer, those receiving BRS experienced a significantly lower rate of AKI (11%) compared to those receiving saline (39%), and BRS was associated with higher magnesium levels post-treatment.
- The findings suggest that hydration with BRS not only helps reduce AKI occurrences but also acts as an independent factor in its prevention, without affecting the rates of hematological toxicity.
Correction: Cardioprotective effect of oleuropein in a cisplatin-induced cardiotoxicity model in rats.
Naunyn Schmiedebergs Arch Pharmacol
August 2024
Veterinary Faculty, Veterinary Physiology Department, Hatay Mustafa Kemal University, Hatay, 31000, Turkey.
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