Site Specific Preparation of N-Glycosylated Peptides: Thioamide-Directed Activation of Aspartate.

Angew Chem Int Ed Engl

School of Chemistry and Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria 3010, Australia.

Published: October 2022

A site-specific method for the preparation of N-glycosylated peptides is described. Incorporation of a peptide backbone thioamide linkage adjacent to an Asp residue facilitates a Ag -promoted, site-specific conversion to N-glycosylated Asn residues in peptides.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9826000PMC
http://dx.doi.org/10.1002/anie.202210367DOI Listing

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