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Tributyltin exposure disrupted the locomotor activity rhythms in adult zebrafish (Danio rerio) and the mechanism involved. | LitMetric

Tributyltin exposure disrupted the locomotor activity rhythms in adult zebrafish (Danio rerio) and the mechanism involved.

Aquat Toxicol

Ministry of Education Key Laboratory for Ecology of Tropical Islands, Key Laboratory of Tropical Animal and Plant Ecology of Hainan Province, College of Life Sciences, Hainan Normal University, Haikou, Hainan 571158, China. Electronic address:

Published: October 2022

AI Article Synopsis

Article Abstract

The fish circadian rhythm system might be an emerging target of tributyltin (TBT), however, the mechanism by which TBT interferes with the circadian rhythm is poorly understood. Therefore, in the present study, zebrafish were used to assess the effects of TBT at environmental concentrations (1 and 10 ng/L) on locomotor activity rhythm. Furthermore, we focused on the visual system to explore the potential mechanism involved. After 90 d of exposure, TBT disturbed the locomotor activity rhythms in zebrafish, which manifested as: (1) low activities and lethargy during the arousing period; (2) inability to fall asleep quickly and peacefully during the period of latency to sleep; and (3) no regular "waves" of locomotor activities during the active period. After TBT exposure, the histological structure of the eyes significantly changed, the boundary between layers became blurred, and the melanin concentrations significantly decreased. Using KEGG and GSEA pathway analyses, the differentially expressed genes in the eyes screened by transcriptomics were significantly enriched in the tyrosine metabolism pathway and retinol metabolism pathway. Furthermore, a decrease in melanin and disruption of retinoic acid were found after TBT exposure, which would affect the reception of phototransduction, and then interfere with the circadian rhythm in fish. The disruption of the circadian rhythm of fish by aquatic pollutants would decrease their ecological adaptability, which should be considered in future research.

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http://dx.doi.org/10.1016/j.aquatox.2022.106287DOI Listing

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