AI Article Synopsis
- The hydrophobic surfactant BEP, when administered with lipid emulsion to rats, impacted the transport of triglycerides and cholesterol in the intestines, specifically reducing large intestinal triglyceride-rich lipoproteins (TRLp).
- The treatment led to a decrease in non-apoB apolipoproteins in larger TRLp while increasing them in smaller TRLp, but the overall content of apoB protein increased due to more small TRLp.
- Once BEP was stopped, the intestinal lipid transport system quickly returned to normal function, suggesting that the inhibition of lipid transport was not due to a lack of important apolipoproteins.
Article Abstract
Hydrophobic surfactant BEP was administered intraduodenally as part of lipid emulsion to rats with cannulated mesenteric lymphatic duct. The effect on the size and composition of intestinal triglyceride-rich lipoproteins (TRLp) was assessed by comparing the results with those obtained during infusion of the lipid emulsion alone. Administration of BEP decreased intestinal capacity to transport triglyceride and cholesterol in large TRLp, SF greater than 2000, and resulted in a significant reduction of total triglyceride in lymph. Non-apoB apolipoproteins decreased significantly in large and increased in small TRLp without appreciable change in total content. Contrary to these findings total apoB protein content increased significantly, primarily due to an increase in small TRLp. Changes in lipid and protein content of apolipoproteins produced by BEP resulted in increased ratios of apolipoproteins to lipids in TRLp. It was therefore concluded that inhibition of lipid transport by BEP was not a result of apolipoprotein deficiency. Discontinuation of BEP administration resulted in a prompt recovery of the intestinal lipid transport system.
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| http://dx.doi.org/10.1016/0021-9150(87)90243-7 | DOI Listing |
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