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Exploring Shared Targets in Cancer Immunotherapy and Cancer-Induced Bone Pain: Insights from Preclinical Studies.
Cancer Lett
December 2024
Department of Integrative Medicine and Neurobiology, School of Basic Medical Sciences, Shanghai Medical College, Institute of Acupuncture Research, Institutes of Integrative Medicine, Fudan University, Shanghai 200032, China; Shanghai Key Laboratory of Acupuncture Mechanism and Acupoint Function, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University, Shanghai 200032, China. Electronic address:
Cancer casts a profound shadow on global health, with pain emerging as one of the dominant and severe complications, particularly in advanced stages. The effective management of cancer-induced pain remains an unmet need. Emerging preclinical evidence suggests that targets related to tumor immunotherapy may also modulate cancer-related pain pathways, thus offering a promising therapeutic direction.
View Article and Find Full Text PDFRobust In Vitro Models for Studying Parkinson's Disease? LUHMES Cells and SH-SH5Y Cells.
Int J Mol Sci
December 2024
Cellular Physiology Research Lab, School of Medicine, Department of Physiology, University of Galway, H91W5P7 Galway, Ireland.
As our population ages, there is an increased unmet clinical need surrounding neurodegenerative diseases such as Parkinson's disease (PD). To tackle this ever-increasing problem, we must ensure that the cell models that we use to develop therapeutics in vitro are robust, reliable, and replicable. In this study, we compared SH-SY5Y cells with LUHMES cells in response to 6-Hydroxydopamine (6OHDA) and 1-Methyl-4-phenylpyridinium (MPP+), two common Parkinson's insults used in in vitro analysis.
View Article and Find Full Text PDFInternational PCOS guideline clinical research priorities roadmap: a co-designed approach aligned with end-user priorities in a neglected women's health condition.
EClinicalMedicine
December 2024
Monash Centre for Health Research and Implementation, Monash University, Melbourne, VIC, Australia.
Article Synopsis
- Polycystic ovary syndrome (PCOS) is a prevalent health issue that can lead to various reproductive, metabolic, and psychological problems, highlighting the need for a collective approach to establish research priorities in this field.
- A comprehensive process involving international surveys, systematic reviews, and peer validation revealed over 150 key research priorities, focusing on diagnosis, care models, patient information, lifestyle management, and fertility treatments for those with PCOS.
- The resulting clinical research roadmap aims to direct future studies according to the needs and interests of women with PCOS and healthcare providers, addressing this commonly overlooked condition.
Lipid extract from Black Soldier Fly larvae: A high value excipient for solid lipid nanoparticles tailored to tackle atopic dermatitis.
Int J Pharm
December 2024
CBIOS, Universidade Lusófona's Research Center for Biosciences & Health Technologies, Lisboa, Portugal. Electronic address:
Atopic dermatitis (AD) is a chronic inflammatory skin disorder with a complex pathogenesis involving epidermal barrier dysfunction and aberrant lipid composition, particularly ceramides and fatty acids (FA). Conventional management options, such as topical glucocorticoids (GC), often lead to adverse effects upon prolonged usage, prompting the exploration of alternative therapeutic strategies. The lipid extract from Black Soldier Fly larvae (BSFL) biomass, holding a rich blend of FA, holds substantial potential as a novel ingredient to tackle skin barrier impairment.
View Article and Find Full Text PDFLiposomes and Their Therapeutic Applications in Enhancing Psoriasis and Breast Cancer Treatments.
Nanomaterials (Basel)
November 2024
School of Pharmacy and Pharmaceutical Sciences, University of Sunderland, Sunderland SR1 3SD, UK.
Psoriasis and breast cancer are two examples of diseases where associated inflammatory pathways within the body's immune system are implicated. Psoriasis is a complex, chronic and incurable inflammatory skin disorder that is primarily recognized by thick, scaly plaques on the skin. The most noticeable pathophysiological effect of psoriasis is the abnormal proliferation of keratinocytes.
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