AI Article Synopsis
Article Abstract
The present study identified the probable mechanism behind the anti-cancer activity of the hexane fraction of Pleurotus osteratus (HFPO) using network pharmacology and experimental validation. HFPO myco-metabolites targets and targets related to the cancer were mined from the online web server, and overlapping targets were screened. Out of the 74 overlapping targets, 33 targets were identified in the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway of cancer. Furthermore, the main active myco-metabolites and hub targets were identified by network analysis of the compound-targets network and protein-protein interaction (PPI), respectively. Molecular docking results showed good binding affinity of the hub targets with their respective myco-metabolites. HFPO induced in-vitro anti-cancer activity by affecting the PI3K-AKT-mTOR pathway, besides time-dependent cell cytotoxicity and apoptotic cell body formation. Additionally, tumor volume reduction was observed in HFPO-treated Ehrlich ascites carcinoma (EAC) bearing Swiss albino mice. Overall, HFPO induces anti-cancer potential by modulating the PI3K-AKT-mTOR signaling pathway.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s12010-022-04111-3 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The feasibility of partial replacement of berseem hay by spent mushroom () substrate in rabbit diets on growth performance, digestibility, caecum fermentation, and economic efficiency.
Arch Anim Nutr
December 2023
Department of Fish and Animal Production, Faculty of Agriculture (Saba Basha), Alexandria University, Alexandria, Egypt.
Nowadays, agricultural by-product disposal is a major concern. The mushroom by-products could be used as an alternative feed source in rabbit diets. Therefore, partial replacement of berseem hay (BH) with spent mushroom substrate (SMS) was conducted in four experimental groups as follows: 0, 20, 40, and 60% of SMS.
View Article and Find Full Text PDFChemometric-Based Analysis of Metabolomics Studies of Bioactive Fractions of Pleurotus osteratus and Their Correlation with In Vitro Anti-Cancer Activity.
Appl Biochem Biotechnol
July 2023
Phytomedicine Research Laboratory, Department of Pharmaceutical Engineering & Technology, IIT (BHU), Varanasi, 221005, India.
Article Synopsis
- Pleurotus osteratus is highlighted for its nutrient richness and bioactive compounds, showing potential anti-cancer effects against breast cancer cells through the evaluation of its various extracts.
- The study found that the hexane fraction of the mushroom exhibited the highest cytotoxicity, followed by the ethyl acetate and crude extracts, while identifying polyphenol and ergosterol as key compounds linked to these effects.
- Advanced mass spectrometry techniques revealed diverse myco-metabolites, with chemometric analysis indicating potential synergistic interactions among the metabolites that contribute to the observed anti-cancer activity.
Tracing the Anti-cancer Mechanism of Pleurotus osteratus by the Integrative Approach of Network Pharmacology and Experimental Studies.
Appl Biochem Biotechnol
January 2023
Phytomedicine Research Laboratory, Department of Pharmaceutical Engineering & Technology, Indian Institute of Technology (BHU), Varanasi, 221005, India.
The present study identified the probable mechanism behind the anti-cancer activity of the hexane fraction of Pleurotus osteratus (HFPO) using network pharmacology and experimental validation. HFPO myco-metabolites targets and targets related to the cancer were mined from the online web server, and overlapping targets were screened. Out of the 74 overlapping targets, 33 targets were identified in the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway of cancer.
View Article and Find Full Text PDFImproving Nutritive Value of Purple Field Corn Residue and Rice Straw by Culturing with White-Rot Fungi.
J Fungi (Basel)
May 2020
Tropical Feed Resources Research and Development Center (TROFREC), Department of Animal Science, Faculty of Agriculture, Khon Kaen University, Khon Kaen 40002, Thailand.
It was hypothesized that white-rot fungus fermented with rice straw and purple field corn improves nutrient utilization via enhanced digestibility and lowers methane (CH) production due to the effects of the lovastatin compound. The aim of the current experiment was to investigate the effect of inoculation of two fungi belonging to white-rot fungus type on feed value and ruminal fermentation characteristic. The experiment was carried out according to a completely randomized 3 × 3 factorial design: three roughage sources (rice straw, purple corn stover, and purple corn field cob) for three inoculation methods (untreated, treated, and treated).
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!