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Angiomatoid fibrous histiocytoma with EWSR1-CREB1 gene fusion occurs in lungs and ribs with systemic multiple metastases: a case report and review of the literature.
Front Oncol
January 2025
Department of Pathology, The First Affiliated Hospital of Dali University, Dali, Yunnan, China.
Angiomatoid fibrous histiocytoma (AFH) is a rare soft tissue tumor with intermediate malignant potential, and it rarely metastasizes. We encountered a unique AFH case where, the tumor was discovered initially in unusual locations-the left lung and the left 4th rib. Combined histological features with FISH and NGS analysis, the diagnosis of AFH was supported, however, it is difficult to determine which of these two is the primary lesion.
View Article and Find Full Text PDFAn Unusual Case Report of Duodenojejunal Flexure Tumor With a Systematic Review of the Literature.
Cureus
December 2024
Gastroenterology and Hepatology, Kalinga Institute of Medical Sciences, Bhubaneswar, IND.
The small intestine is the longest segment of the gastrointestinal (GI) tract, but cancers in the small intestine are infrequent. The duodenojejunal (DJ) flexure is an uncommon site for tumors, and those located in these sites are difficult to identify and manage properly. Their rarity, along with ambiguous symptoms that can be readily misattributed to milder conditions, results in a delayed diagnosis when the tumors have significantly advanced.
View Article and Find Full Text PDFReactivity of Anomalous Aziridines for Versatile Access to High Fsp Amine Chemical Space.
Acc Chem Res
January 2025
Department of Chemistry, University of Wisconsin, 1101 University Avenue, Madison, Wisconsin 53706, United States.
ConspectusThe manipulation of strained rings is a powerful strategy for accessing the valuable chemical frameworks present in natural products and active pharmaceutical ingredients. Aziridines, the smallest N-containing heterocycles, have long served as building blocks for constructing more complex amine-containing scaffolds. Traditionally, the reactivity of typical aziridines has been focused on ring-opening by nucleophiles or the formation of 1,3-dipoles.
View Article and Find Full Text PDFVentricular lead malfunction in a patient with complete atrioventricular block and corrected transposition of the great arteries: Is leadless pacemaker the best solution?
J Cardiol Cases
October 2024
Second Division of Cardiology, Pisa University Hospital, Pisa, Italy.
Unlabelled: Corrected transposition of the great arteries (c-TGA) is a congenital abnormality characterized by atrioventricular (AV) and ventriculoarterial discordance, associated with early and late-onset conduction disturbances. We report the case of a c-TGA patient affected by congenital complete AV block, with right ventricular lead malfunction with prolonged dwell time and two abandoned leads. He underwent leadless VDD pacemaker implantation at an unusual site (i.
View Article and Find Full Text PDFThe actin-based motility effectors RickA and Sca2 contribute differently to cell-to-cell spread and pathogenicity.
mBio
January 2025
Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California, USA.
is an obligate intracellular, tick-borne bacterial pathogen that can cause eschar-associated rickettsiosis in humans. invades host cells, escapes from vacuoles into the cytosol, and undergoes two independent modes of actin-based motility mediated by effectors RickA or Sca2. Actin-based motility of enables bacteria to enter protrusions of the host cell plasma membrane that are engulfed by neighboring host cells.
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