Aim: In this study, we investigated the effects of necrostatin-1 (NEC-1) on subarachnoid hemorrhage (SAH)-induced vasospasm in a rat model.
Material And Methods: 59 male Wistar albino rats were randomly divided into six groups: control (group 1), sham (group 2), decapitation one hour after SAH (group 3), decapitation 48 hours after SAH (group 4), NEC-1 given 15 minutes before SAH and decapitation one hour after SAH (group 5), and NEC-1 given 24 hours after SAH and decapitation 48 hours after SAH (group 6). NEC-1 (1 uq) was administered intracisternally in dimethyl sulfoxide (DMSO) (2.6 uq). After decapitation, the cross-sectional areas and wall thicknesses of basilar arteries were determined histopathologically using stereological methods.
Results: NEC-1 administered before SAH had a statistically significant preventive effect on vasospasm following SAH. Arterial wall thicknesses were found to be significantly increased in the SAH without NEC-1 groups but not in the control group, the sham group or the NEC-1 groups.
Conclusion: The results of this study show that NEC-1 can prevent vasospasm in rats and has cytoprotective effects. Further studies are needed for the clinical use of this agent.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.5137/1019-5149.JTN.35167-21.4 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
KOBu-Promoted [3 + 2] Cycloaddition of Dimethyl Sulfoxide with Fullerenes.
Org Lett
January 2025
State Key Laboratory for Physical Chemistry of Solid Surfaces, Collaborative Innovation Center of Chemistry for Energy Materials, Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, Fujian 361005, People's Republic of China.
KOBu-promoted [3 + 2] cycloaddition of dimethyl sulfoxide (DMSO) with fullerenes has been developed for facile and efficient one-pot synthesis of 1,2,3,4-cyclic sulfoxide-fused [60]/[70]fullerene dihydrides, which offers a versatile platform for the site-selective preparation of various fullerene multiadducts with a wide range of functional groups. The utility of these tetra-functionalized fullerenes is demonstrated by the successful application as electron-transport materials in perovskite solar cells.
View Article and Find Full Text PDFLyme disease associated neurological and musculoskeletal symptoms: A systematic review and meta-analysis.
Brain Behav Immun Health
February 2025
University Center for Research and Development, Chandigarh University, Mohali, Punjab, India.
Background And Objective: Lyme disease, caused by , presents major health challenges worldwide, leading to serious neurological and musculoskeletal issues that impact patients' lives and healthcare systems. This systematic review and meta-analysis aim to determine the prevalence and link between Lyme disease and these complications, aiming to enhance clinical and public health approaches.
Methods: We systematically searched PubMed, EMBASE, and Web of Science up until April 01, 2024, to find studies reporting the prevalence and severity of neurological and musculoskeletal complications associated with Lyme disease.
Prevalence of dengue and leptospirosis coinfection and associated mortality rates: a systematic review and meta-analysis.
BMC Infect Dis
January 2025
School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, India.
Background: Dengue and leptospirosis are prominent vector-borne diseases in tropical and subtropical regions, sharing overlapping geographic distribution and clinical presentations, which complicates diagnosis and management. Co-infection of these pathogens places additional strain on healthcare resources in endemic areas. This study aims to systematically estimate the prevalence and mortality rates of dengue and leptospirosis co-infections and assess their clinical implications.
View Article and Find Full Text PDFAuricular vagus nerve stimulation for mitigation of inflammation and vasospasm in subarachnoid hemorrhage: a single-institution randomized controlled trial.
J Neurosurg
January 2025
Departments of1Neurosurgery.
Objective: Inflammation contributes to morbidity following subarachnoid hemorrhage (SAH). The authors of this study evaluate how applying noninvasive transauricular vagus nerve stimulation (taVNS) can target this deleterious inflammatory response following SAH and reduce the rate of radiographic vasospasm.
Methods: In this prospective, triple-blinded, randomized controlled trial, 27 patients were randomized to taVNS or sham stimulation.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!