AI Article Synopsis
- A systematic review was conducted on postoperative recurrence rates in patients with atypical meningiomas, analyzing 29 studies and 3122 patients up to July 2021.
- The overall recurrence rate was found to be 38%, with specific factors showing varying impacts: older patients had a recurrence rate of 51%, while younger ones had 40%, and male and female rates were similar at 42% and 44%.
- Additional factors like tumor location, mitotic count, and extent of resection significantly influenced recurrence rates, highlighting the need for enhanced monitoring and treatment strategies post-surgery to improve patient outcomes.
Article Abstract
Objective To systematically review the overall status of postoperative recurrence in patients with atypical meningiomas. Methods China National Knowledge Infrastructure,Wanfang Database,Chinese Biomedical Literature Database,VIP Database,PubMed,Embase,Web of Science,and Cochrane Library were searched for collection of the relevant literature on the recurrence of atypical meningioma from database establishment to July 2021.Two investigators independently screened the literature,extracted data,and assessed the risk of bias of the included studies,and then performed a meta-analysis by using R 5.0. Results A total of 29 studies involving 3122 patients were included in this study.The meta-analysis showed that the overall postoperative recurrence rate of atypical meningioma was 38%.The subgroup analysis showed that the tumor recurrence rate of patients ≥60 years old and<60 years old was 51% and 40%,respectively,with no significant difference.The tumor recurrence rates in male and female patients were 42% and 44%,respectively,which showed no significant difference.The recurrence rates of the patients with parasagittal meningiomas,brain tissue infiltration,Ki-67>8%,mitotic count ≥6/10 high-power fields,and tissue necrosis were 52%,47%,63%,53%,and 69%,respectively.The recurrence rate after subtotal tumor resection was as high as 58%,and the patients who received radiotherapy had higher tumor recurrence rate than that those who did not receive radiotherapy (38% 29%,=0.007). Conclusions The current evidence demonstrates that atypical meningioma has a high recurrence rate after surgery.It is essential to pay more attention and take corresponding measures to improve the tumor-free survival rate of the patients.
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| http://dx.doi.org/10.3881/j.issn.1000-503X.14435 | DOI Listing |
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