AI Article Synopsis
- The osteosarcoma (OS) microenvironment consists of tumor cells, immune cells, and stromal tissue, playing a crucial role in OS development and progression, which highlights the need for microenvironment-targeted treatments.
- Using principal component analysis on 88 OS cases, researchers developed a TME scoring system identifying high and low TMEscore phenotypes, with high scores linked to longer patient survival and better treatment responses.
- These findings were confirmed through additional data analysis and laboratory experiments, providing insights into immune interactions in OS and potential new therapeutic approaches.
Article Abstract
The osteosarcoma (OS) microenvironment is composed of tumor cells, immune cells, and stromal tissue and is emerging as a pivotal player in OS development and progression. Thus, microenvironment-targeted strategies are urgently needed to improve OS treatment outcomes. Using principal component analysis (PCA), we systematically examined the tumor microenvironment (TME) and immune cell infiltration of 88 OS cases and constructed a TME scoring system based on the TMEscore high and TMEscore low phenotypes. Our analysis revealed that TMEscore high correlates with longer survival in OS patients, elevated immune cell infiltration, increased immune checkpoints, and increased sensitivity to chemotherapy. TMEscore low strongly correlated with immune exclusion. These observations were externally validated using a GEO dataset (GSE21257) from 53 OS patients. Our laboratory data also proved our findings. This finding enhances our understanding of the immunological landscape in OS and may uncover novel targeted therapeutic strategies.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9440849 | PMC |
| http://dx.doi.org/10.1155/2022/6568278 | DOI Listing |
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