Vinylboron compounds are important compounds in organic chemistry and biology. In this communication, we developed a copper(I)-catalyzed, highly regio- and stereoselective radical -hydroboration of ynamides with -heterocyclic carbene (NHC)-ligated borane is reported, which leads to a series of -boryl enmides that can be conveniently transformed into various multi-substituted enamides. Further investigation showcased that our method is robust and scalable. The mechanism of this unique reaction is studied and discussed.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9440302 | PMC |
| http://dx.doi.org/10.1016/j.isci.2022.104977 | DOI Listing |
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