AI Article Synopsis
- The hippocampus is essential for cognitive functions like learning and memory, traditionally studied within its layered structure (transverse plane) and key regions like the dentate gyrus and CA areas.
- Recent research focuses on the importance of interlamellar (longitudinal) projections, which enhance our understanding of how signals converge and diverge within cognitive processes.
- This review highlights the role of longitudinal connections in cognition, presents a potential mechanism for place coding, and encourages a new perspective on hippocampal circuitry.
Article Abstract
The hippocampus is regarded as a cognition hub, particularly for learning and memory. Previously, neuronal mechanisms underlying various cognitive functions are delineated with the lamellar hippocampal circuitry, dentate gyrus-CA3 or CA2-CA1, within the transverse plane. More recently, interlamellar (often referred to as longitudinal) projections have received intensive attention to help understand signal convergence and divergence in cognition and behavior. Signal propagation along the longitudinal axis is evidenced by axonal arborization patterns and synaptic responses to electro- and photo-stimulation, further demonstrating that information flow is more enriched in the longitudinal plane than the transverse plane. Here, we review the significance of longitudinal connections for cognition, discuss a putative circuit mechanism of place coding, and suggest the reconceptualization of the hippocampal circuitry.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9826151 | PMC |
| http://dx.doi.org/10.1002/jcp.30868 | DOI Listing |
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