Hybrid exoskeletons, which combine functional electrical stimulation (FES) with a motorized testbed, can potentially improve the rehabilitation of people with movement disorders. However, hybrid exoskeletons have inherently nonlinear and uncertain dynamics, including combinations of discrete modes that switch between different continuous dynamic subsystems, which complicate closed-loop control. A particular complication is the uncertain muscle control effectiveness associated with FES. In this work, adaptive integral concurrent learning (ICL) motor and FES controllers are developed for a hybrid biceps curl exoskeleton, which are designed to achieve opportunistic and data-based learning of the uncertain human and electromechanical testbed parameters. Global exponential trajectory tracking and parameter estimation errors are proven through a Lyapunov-based stability analysis. The motor effectiveness is assumed to be unknown, and, to help with fatigue reduction, FES is enabled to switch between multiple electrodes on the biceps brachii, further complicating the analysis. A consequence of switching between the different uncertain subsystems is that the parameters must be opportunistically learned for each subsystem (i.e. each electrode and the motor), while that subsystem is active. Experiments were performed to validate the developed ICL controllers on twelve healthy participants. The average (± standard deviation) position tracking errors across each participant were 1.44 ± 5.32 deg, -0.25 ± 2.85 deg, and -0.17 ± 2.66 deg across biceps Curls 1-3, 4-7, and 8-10, respectively, where the average across the entire experiment was 0.28 ± 3.53 deg.
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http://dx.doi.org/10.1109/TNSRE.2022.3204247 | DOI Listing |
Clin Pharmacol Ther
January 2025
Certara Predictive Technologies Division, Certara UK Limited, Sheffield, UK.
Understanding cytokine-related therapeutic protein-drug interactions (TP-DI) is crucial for effective medication management in conditions characterized by elevated inflammatory responses. Recent FDA and ICH guidelines highlight a systematic, risk-based approach for evaluating these interactions, emphasizing the need for a thorough mechanistic understanding of TP-DIs. This study integrates the physiologically based pharmacokinetic (PBPK) model for TP (specifically interleukin-6, IL-6) with small-molecule drug PBPK models to elucidate cytokine-related TP-DI mechanistically.
View Article and Find Full Text PDFInt J Exerc Sci
December 2024
School of Health Promotion and Kinesiology, Texas Woman's University, Denton, TX, USA.
The purpose of this study was to compare changes in circulating microRNAs -126 (c-miR-126) and -222 (c-miR-222) following acute serial concurrent exercise (SCE) and integrated concurrent exercise (ICE) sessions among young, sedentary adults. Ten males and 9 females completed the study procedures. For SCE, participants performed resistance exercise (RE) followed by aerobic exercise (AE), without mixing the two.
View Article and Find Full Text PDFJ R Stat Soc Ser C Appl Stat
January 2025
Department of Biostatistics and Health Data Science, School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.
The aim of dynamic prediction is to provide individualized risk predictions over time, which are updated as new data become available. In pursuit of constructing a dynamic prediction model for a progressive eye disorder, age-related macular degeneration (AMD), we propose a time-dependent Cox survival neural network (tdCoxSNN) to predict its progression using longitudinal fundus images. tdCoxSNN builds upon the time-dependent Cox model by utilizing a neural network to capture the nonlinear effect of time-dependent covariates on the survival outcome.
View Article and Find Full Text PDFMath Biosci Eng
December 2024
Department of Mathematics & Statistics, Georgia State University, Atlanta, USA.
Control and prevention strategies are indispensable tools for managing the spread of infectious diseases. This paper examined biological models for the post-vaccination stage of a viral outbreak that integrate two important mitigation tools: social distancing, aimed at reducing the disease transmission rate, and vaccination, which boosts the immune system. Five different scenarios of epidemic progression were considered: (ⅰ) the "no control" scenario, reflecting the natural evolution of a disease without any safety measures in place, (ⅱ) the "reconstructed" scenario, representing real-world data and interventions, (ⅲ) the "social distancing control" scenario covering a broad set of behavioral changes, (ⅳ) the "vaccine control" scenario demonstrating the impact of vaccination on epidemic spread, and (ⅴ) the "both controls concurrently" scenario incorporating social distancing and vaccine controls simultaneously.
View Article and Find Full Text PDFPaediatr Drugs
January 2025
National Centre for Register-based Research, Aarhus University, Fuglesangs Allé 26, 8210, Aarhus V, Denmark.
Background And Objectives: Females of reproductive age are increasingly using attention deficit hyperactivity disorder (ADHD) medication, but its use during pregnancy and breastfeeding is largely unknown. The aim of this study is to examine the prevalence of ADHD medication fills during pregnancy and breastfeeding, including characteristics of these females and cohort differences over time.
Methods: We conducted a descriptive study using Danish nationwide registers.
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