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Purpose: To explore the potential of deuterium metabolic imaging (DMI) in the human brain in vivo at 7 T, using a multi-element deuterium ( H) RF coil for 3D volume coverage.
Methods: H-MR images and localized H MR spectra were acquired in vivo in the human brain of 3 healthy subjects to generate DMI maps of H-labeled water, glucose, and glutamate/glutamine (Glx). In addition, non-localized H-MR spectra were acquired both in vivo and in vitro to determine T and T relaxation times of deuterated metabolites at 7 T. The performance of the H coil was assessed through numeric simulations and experimentally acquired B maps.
Results: 3D DMI maps covering the entire human brain in vivo were obtained from well-resolved deuterated ( H) metabolite resonances of water, glucose, and Glx. The T and T relaxation times were consistent with those reported at adjacent field strengths. Experimental B maps were in good agreement with simulations, indicating efficient and homogeneous B transmission and low RF power deposition for H, consistent with a similar array coil design reported at 9.4 T.
Conclusion: Here, we have demonstrated the successful implementation of 3D DMI in the human brain in vivo at 7 T. The spatial and temporal nominal resolutions achieved at 7 T (i.e., 2.7 mL in 28 min, respectively) were close to those achieved at 9.4 T and greatly outperformed DMI at lower magnetic fields. DMI at 7 T and beyond has clear potential in applications dealing with small brain lesions.
Download full-text PDF |
Source |
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9756916 | PMC |
http://dx.doi.org/10.1002/mrm.29439 | DOI Listing |
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