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OGT::FOXO1-fused myoepithelioma-like hyalinising epithelioid tumour arising in non-acral skin.
Pathology
October 2024
Department of Pathology, Université de Tours, Centre Hospitalier Universitaire de Tours, Tours, France; "Biologie des Infections à Polyomavirus" Team, UMR INRA ISP 1282, Université de Tours, Tours, France; CARADERM Network, France. Electronic address:
Myoepithelioma-like hyalinizing epithelioid tumor of the foot with OGT-FOX03 fusion gene: Imaging findings, surgical implications, and pathological correlates.
Radiol Case Rep
March 2023
Department of Hematology and Oncology, University of Florida College of Medicine Jacksonville, Jacksonville, FL 32209, USA.
Myoepithelioma-like hyalinizing epithelioid tumors are rare neoplasms that share morphological characteristics of myoepitheliomas but lack traditional immunophenotypic findings. Though little is known about these tumors at present, a handful of recent studies have confirmed that they harbor a novel fusion gene known as "OGT-FOXO." Though closely resembling myoeptheliomas, Myoepithelioma-like hyalinizing epithelioid tumors are considered a distinct tumor entity, and few studies have explored their clinical characteristics or their potential for malignancy.
View Article and Find Full Text PDFMyoepithelioma-like hyalinising epithelioid tumour of the foot: biopsy diagnosis, with molecular confirmation.
Histopathology
December 2022
Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Hyalinizing epithelioid tumors with OGT-FOXO fusions. A case report of a non-acral soft tissue mass harboring a novel FOXO4 gene rearrangement.
Genes Chromosomes Cancer
July 2021
Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Recurrent fusions between OGT and members of the Forkhead box (FOXO) family of genes have been recently described in three cases of hyalinizing epithelioid acral soft tissue tumors in young adults showing co-expression for EMA and CD34. Despite the lack of an established myoepithelial lineage by immunohistochemistry, these lesions have been labeled as myoepithelioma-like due to their epithelioid phenotype and sclerotic background. In this study, we report a novel FOXO4-OGT fusion identified by targeted RNA sequencing in an unclassified shoulder soft tissue mass in a 40-year-old male.
View Article and Find Full Text PDFMyoepithelioma-like Hyalinizing Epithelioid Tumor of the Foot Harboring an OGT-FOXO1 Fusion.
Am J Surg Pathol
February 2021
Departments of Pathology.
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