AI Article Synopsis

  • The study combined this gel with solid microneedles of various lengths to enhance its absorption through the skin barrier, with results showing that microneedles improved VAL permeation by up to three times compared to untreated skin.
  • Testing indicated that the formulations were safe and effective, with the best results achieved using 1.5 mm microneedles, allowing for 1.69 mg of VAL to penetrate the skin after 8 hours, highlighting the potential for this method in treating hypertension.

Article Abstract

Valsartan (VAL) is used as a first-line agent to treat hypertension. However, VAL exhibits poor absorption and low bioavailability when administrated orally. To overcome these issues, VAL transdermal gel was developed in this study, where Carbopol was used as the gel matrices. Additionally, solid microneedles (Dermaroller) with various needle lengths were combined with transdermal gel to improve its permeation across the stratum corneum as a skin barrier. Developed formulations were further evaluated for various parameters, including pH, viscosity, spreadability, extrudability, gel strength, drug content, permeation, release, occlusivity, and hemolysis. The results showed that all formulations exhibited desired physical characteristics without any potential to cause toxicity. Moreover, this approach showed that using microneedles could significantly enhance the permeation of VAL up to 3 folds compared to untreated skin. The use of microneedles 1.5 mm was found to be the optimum combination to improve VA permeation without affecting skin integrity. As much as 1.69 ± 0.004 mg of VAL permeated after 8 h. Finally, it could be concluded that this work had successfully developed a new approach for VALS drug delivery and could potentially show a significant impact on the treatment of hypertension. Further work should be considered.

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Source
http://dx.doi.org/10.1080/09205063.2022.2121590DOI Listing

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