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Antibiotic release from PMMA spacers and PMMA beads measured with ELISA: Assessment of in vitro samples and drain fluid samples of patients.
J Orthop Res
August 2023
Department of Orthopaedic Surgery, Laboratory for Experimental Orthopaedics, Research School CAPHRI, Maastricht University Medical Centre+, Maastricht, The Netherlands.
For prosthetic joint infections, antibiotic loaded poly methyl methacrylate (PMMA) spacer or beads can be used to release high concentrations of antibiotics locally at the infection site, while minimizing systemic toxicity. The aim of this study is to determine in vitro and in vivo pharmacokinetic release profile of antibiotics from PMMA spacers and PMMA beads. For the in vitro experiment, the PMMA spacers or beads were submerged in phosphate-buffered saline and gentamicin concentrations were determined from collected specimen at several times points, measured with enzyme-linked immunosorbent assays (ELISA).
View Article and Find Full Text PDFPhysicochemical characteristics of lignin-g-PMMA/PLA blend via atom transfer radical polymerization depending on the structural difference of organosolv lignin.
Int J Biol Macromol
January 2023
Department of Agriculture, Forestry, and Bioresources, College of Agriculture and Life Sciences, Seoul National University, Seoul 08826, Republic of Korea; Research Institute of Agriculture and Life Sciences, College of Agriculture and Life Sciences, Seoul National University, Seoul 08826, Republic of Korea. Electronic address:
Lignin has different structural characteristics depending on the extraction conditions. In this study, three types of ethanol organosolv lignin (EOL) were produced under different extraction conditions involving the reaction temperature (140, 160, 180 °C), sulfuric acid concentration (0.5, 1, 1.
View Article and Find Full Text PDFSynthesis of Starch-Grafted Polymethyl Methacrylate via Free Radical Polymerization Reaction and Its Application for the Uptake of Methylene Blue.
Molecules
September 2022
Department of Life Sciences, School of Science, University of Management and Technology (UMT), C-II Johar Town, Lahore 54770, Pakistan.
In this research, a new biodegradable and eco-friendly adsorbent, starch-grafted polymethyl methacrylate (St-g-PMMA) was synthesized. The St-g-PMMA was synthesized by a free radical polymerization reaction in which methyl methacrylate (MMA) was grafted onto a starch polymer chain. The reaction was performed in water in the presence of a potassium persulfate (KPS) initiator.
View Article and Find Full Text PDFOsteomyelitis and Gentamicin-PMMA Chains.
Clin Nucl Med
November 2022
From the Department of Nuclear Medicine, Centre Hospitalier du Mans, Le Mans, France.
In chronic osteomyelitis, effective local antibiotic therapy after surgical debridement can be achieved by implantation of gentamicin-PMMA chains. The gentamicin concentrations at the site of infection are higher than that after systemic application of the same antibiotic. The appearance of this treatment is a particular aspect from a radiological point of view.
View Article and Find Full Text PDFRechargeable anticandidal denture material with sustained release in saliva.
Oral Dis
July 2016
Geriatric Research, Education and Clinical Center and Research Service, Audie L Murphy Division, South Texas Veterans Health Care System, San Antonio, TX, USA.
Objective: Candida-induced denture stomatitis is a common debilitating problem among denture wearers. Previously, we described the fabrication of a new denture material that released antifungal drugs when immersed in phosphate buffered saline. Here, we use more clinically relevant immersion conditions (human saliva; 37°C) and measure miconazole release and bioactivity.
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