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Outcomes of a High-Volume Organ Procurement Organization in the Era of Increasing Donation After Circulatory Death. | LitMetric

AI Article Synopsis

  • - The study investigates the rising trend of Donation after Circulatory Death (DCD) in the U.S., focusing on the donation process from referral to transplantation and identifying disparities based on donor type.
  • - Data from 2018 revealed there were 2,466 organ donation referrals, with distinct differences in authorization rates linked to donor types, demographics, and factors like age and ethnicity.
  • - The analysis emphasizes the need for better strategies to boost organ utilization from DCD donors, highlighting that issues such as next-of-kin authorization and pre-mortem heparin use play significant roles in this process.

Article Abstract

Donation after circulatory death (DCD) is rapidly increasing in the United States. Detailed data outlining the process from referral to organ transplantation is lacking. We sought to quantify differences at each stage along the referral to donation pathway by donor type. Additionally, we examined factors associated with successful DCD organ utilization. This program evaluation analyzed data from a single organ procurement organization in 2018 to assess demographic and clinical predictors of progression through the donation process, including the role of first-person authorization in DCD. Descriptive statistics were examined by donation stage for demographic characteristics using chi-square; univariate and multivariate logistic regression was used to model predictors of utilization and authorization by organ type, respectively. There were 2466 organ donation referrals during 2018, including 575 donations after brainstem death (DBD), 1890 controlled DCD referrals, and 1 uncontrolled DCD referral. Univariate and multivariate logistic regression models highlighted differences in authorization rates by donor type (DCD vs DBD) and by age, race, and ethnicity. Next-of-kin authorization was declined in 23% of first-person authorized potential DCD, highlighting issues related to the role of donor registration in DCD. Pre-mortem heparin administration was predictive of DCD organ utilization; donor age and warm ischemia time of less than 30 min was statistically significantly associated with DCD extra-renal organ utilization. These results provided insight into strategies for increasing authorization and transplantation of organs from DCD donors and identified areas of improvement for process standardization and policy development.

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Source
http://dx.doi.org/10.1177/15269248221122879DOI Listing

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