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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9396334 | PMC |
| http://dx.doi.org/10.14218/JCTH.2022.00132 | DOI Listing |
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Functional analysis of a panel of molecular markers for diagnosis of systemic lupus erythematosus in rats.
Biosci Rep
July 2024
Department of Biochemistry, Faculty of Pharmacy, Cairo University, 11562, Cairo, Egypt.
Introduction: Systemic lupus erythematosus (SLE) is a diverse autoimmune disease that arises from a combination of complex genetic factors and environmental influences. While circRNAs and miRNAs have recently been identified as promising biomarkers for disease diagnosis, their specific expression patterns, and clinical implications in SLE are not yet fully understood.
Aim Of The Work: The aim of the present study was to determine the role of a panel of noncoding-RNAs specifically circRNAs (circ-TubD1, circ-CDC27, and circ-Med14), along with miRNA (rno-miR-146a-5p) and mRNA (TRAF6), as novel minimally invasive diagnostic biomarkers for experimentally induced SLE.
CircTUBD1: A Novel Circular RNA Molecule as a Therapeutic Target in Radiation-induced Liver Fibrosis.
J Clin Transl Hepatol
August 2022
Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong, China.
CircTUBD1 Regulates Radiation-induced Liver Fibrosis Response via a circTUBD1/micro-203a-3p/Smad3 Positive Feedback Loop.
J Clin Transl Hepatol
August 2022
Department of Radiation Oncology, Zhongshan Hospital, Fudan University, Shanghai, China.
Background And Aims: Radiation-induced liver fibrosis (RILF), delayed damage to the liver (post-irradiation) remains a major challenge for the radiotherapy of liver malignancies. This study investigated the potential function and mechanism of circTUBD1 in the development of RILF.
Methods: By using a dual luciferase assay, RNA pull-down assays, RNA sequencing, chromatin immunoprecipitation (known as ChIP) assays, and a series of gain- or loss-of-function experiments, it was found that circTUBD1 regulated the activation and fibrosis response of LX-2 cells induced by irradiation via a circTUBD1/micro-203a-3p/Smad3 positive feedback loop in a 3D system.
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