Background: encodes the small subunit A of serine palmitoyltransferase. It catalyzes the formation of sphingoid long-chain base backbone of sphingolipids. Its role in glioma prognosis and tumor-infiltrating immune cells remains unclear.
Methods: We analyzed expression and association with clinical prognosis using GEPIA and CGGA database. Then, GSEA was performed to identify relevant biological functions of . The correlations between expression and tumor immune infiltrates were investigated using CIBERSORT and TIMER. Finally, IHC and IF were performed to confirm the value of prognosis and the correlation with immune infiltration.
Results: expression was significantly upregulated in diffuse glioma compared to normal tissues and associated with poor survival in GEPIA and CGGA database. Then, we identified biological processes and signaling pathways associated with expression. The result showed that enriched in the GO term like oxidative stress. Finally, we showed that expression was significantly associated with tumor-infiltrating immune cells and overall survival via IHC.
Conclusion: These findings suggest that expression might be used as a prognostic biomarker for glioma and potential target for novel glioma therapy.
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| http://dx.doi.org/10.1155/2022/6711085 | DOI Listing |
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