Background: Myxovirus resistance protein A (MxA) is a protein that is upregulated by interferon-beta. Homeostatic MxA mRNA levels are potentially correlated with inflammatory disease activity in multiple sclerosis (MS) and could have an important role in MS pathology.
Aim: To investigate the association between myxovirus resistance protein A (MxA) mRNA levels in blood and disease activity and progression in MS over a long-term follow-up period.
Methods: Baseline blood MxA mRNA levels were determined in a prospective cohort of 116 untreated patients with a clinically isolated syndrome (CIS) or early relapsing remitting MS (RRMS), and related to long-term relapses, radiological disease activity, clinical scores [Expanded Disability Status Scale (EDSS), timed-25-foot walk (T25FW), 9-hole-peg test (9HPT)], MS type, and disease modifying therapy (DMT) use.
Results: Low MxA mRNA levels were associated with the occurrence of ≥9 T2-lesions on MRI imaging and the occurrence of relapses during long-term follow-up (median 11 years, IQR 5.91-13.69 years). MxA mRNA levels were not associated with EDSS, T25FW, 9HPT, and MS subtype.
Conclusion: Baseline MxA mRNA levels are associated with long-term development of T2-lesions on MRI-scans in our cohort. This confirms the relevance of the endogenous interferon-beta system in the occurrence of MS disease activity.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9428291 | PMC |
| http://dx.doi.org/10.3389/fneur.2022.907245 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
[Myxovirus resistance protein A (MxA) induces the expression of interferon-stimulated genes in HepG2 cells by enhancing the activity of the interferon-stimulated response element (ISRE)].
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi
August 2024
The Second Hospital of Anhui Medical University, Hefei 230601, China.
Article Synopsis
- - The study investigates the role of Myxovirus resistance protein A (MxA) on the JAK/STAT signaling pathway in HepG2 cells, focusing on the localization and expression of MxA through various biochemical methods.
- - Results showed that MxA is primarily localized in the cytoplasm, and while knocking down MxA does not impact STAT protein levels, it significantly lowers antiviral proteins PKR and OAS expression.
- - Overexpressing MxA increases ISRE activity and boosts PKR and OAS levels, indicating that MxA promotes antiviral protein expression by enhancing the JAK/STAT pathway's activity, though this effect is blocked in HepG2.2.15 cells.
Characterization of the impact of dietary immunostimulant CpG on the expression of mRNA biomarkers involved in the immune responses in Atlantic salmon (Salmo salar).
Fish Shellfish Immunol
October 2024
Department of Ocean Sciences, Memorial University of Newfoundland, St. John's, NL, A1C 5S7, Canada. Electronic address:
Infectious diseases have significantly impacted Atlantic salmon aquaculture worldwide. Modulating fish immunity with immunostimulant-containing functional feeds could be an effective strategy in mitigating disease problems. Previously, we characterized the impact of polyriboinosinic polyribocytidylic acid (pIC) and formalin-killed typical Aeromonas salmonicida bacterin on miRNA expression in Atlantic salmon fed a commercial diet with and without immunostimulant CpG.
View Article and Find Full Text PDFAge-related transcript changes in type I interferon signaling in children and adolescents with long COVID.
Eur J Immunol
May 2024
Department of Molecular Medicine, Laboratory of Virology, Sapienza University of Rome, Rome, Italy.
SARS-CoV-2 typically causes mild symptoms in children, but evidence suggests that persistent immunopathological changes may lead to long COVID (LC). To explore the interplay between LC and innate immunity, we assessed the type I interferon (IFN-I) response in children and adolescents with LC symptoms (LC; n = 28). This was compared with age-matched SARS-CoV-2 recovered participants without LC symptoms (MC; n = 28) and healthy controls (HC; n = 18).
View Article and Find Full Text PDFActivation of Toll-like receptor 3 inhibits HIV infection of human iPSC-derived microglia.
J Med Virol
November 2023
Department of Pathology and Laboratory Medicine, Temple University LewisKatz School of Medicine, Philadelphia, Pennsylvania, USA.
As a key immune cell in the brain, microglia are essential for protecting the central nervous system (CNS) from viral infections, including HIV. Microglia possess functional Toll-like receptor 3 (TLR3), a key viral sensor for activating interferon (IFN) signaling pathway-mediated antiviral immunity. We, therefore, studied the effect of poly (I:C), a synthetic ligand of TLR3, on the activation of the intracellular innate immunity against HIV in human iPSC-derived microglia (iMg).
View Article and Find Full Text PDFCOVID-19 adenovirus vector vaccine induces higher interferon and pro-inflammatory responses than mRNA vaccines in human PBMCs, macrophages and moDCs.
Vaccine
June 2023
Infection and Immunity, Institute of Biomedicine, University of Turku, 20520 Turku, Finland; Turku University Hospital, Clinical Microbiology, 20520 Turku, Finland. Electronic address:
Background: During the COVID-19 pandemic multiple vaccines were rapidly developed and widely used throughout the world. At present there is very little information on COVID-19 vaccine interactions with primary human immune cells such as peripheral blood mononuclear cells (PBMCs), monocyte-derived macrophages and dendritic cells (moDCs).
Methods: Human PBMCs, macrophages and moDCs were stimulated with different COVID-19 vaccines, and the expression of interferon (IFN-λ1, IFN-α1), pro-inflammatory (IL-1β, IL-6, IL-8, IL-18, CXCL-4, CXCL-10, TNF-α) and Th1-type cytokine mRNAs (IL-2, IFN-γ) were analyzed by qPCR.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!