Phosphatidylinositol glycan anchor biosynthesis, class C is a prognostic biomarker and correlates with immune infiltrates in hepatocellular carcinoma.

The exact function of Phosphatidylinositol Glycan Anchor Biosynthesis, Class C gene has yet to be elucidated. In the study, we attempted to clarify the correlations of to prognosis and tumor-infiltrating lymphocytes in hepatocellular carcinoma (HCC). expression was analyzed the Oncomine database, Gene Expression Profiling Interactive Analysis, Hepatocellular carcinoma data base, Human Protein Atlas database and Tumor Immune Estimation Resource (TIMER). We showed the correlation of with the clinical characteristics using UALCAN. We evaluated the influence of on clinical prognosis using Kaplan-Meier plotter databases. And co-expressed genes with and its regulators were identified using LinkedOmics. The correlations between and cancer immune infiltrates were investigated TIMER. We analyzed the drug sensitivity and immunotherapy response via R package. was found up-regulated in tumor tissues in multiple HCC cohorts, also increased in HCC patient with different clinical characteristics. High expression was associated with poorer overall survival. expression showed a strong positive association with the expression of ACBD6, a strong negative association with AGXT212. The cell components and distribution in treatment and non-treatment of HCC patients were quite distinct, which may reveal the relationship between the immunotherapy with tumor microenvironment. Notably, expression was positively correlated with infiltrating levels of immune cells. These findings suggest that is correlated with prognosis and immune infiltrating in HCC, which can be used as a prognostic biomarker for determining prognosis, laying a foundation for further study of the immune regulatory role of in HCC.