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Trends of Brain Stimulation Research in Substance Use Disorder: A Review of ClinicalTrials.gov Registered Trials and Their Publications.
Indian J Psychol Med
December 2024
Dept. of Psychiatry, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India.
Purpose Of The Review: Brain stimulation techniques targeting neuronal pathways are evolving as a novel therapeutic option for substance use disorders. This study aims to provide an overview of the current research landscape on brain stimulation in addiction psychiatry by analyzing data from ClinicalTrials.gov.
View Article and Find Full Text PDFRandomized Controlled Trials of Psilocybin-Assisted Therapy in the Treatment of Major Depressive Disorder: Systematic Review and Meta-Analysis.
Acta Psychiatr Scand
December 2024
Department of Clinical Psychopharmacology and Neurotoxicology, National Institute of Mental Health and Neurosciences, Bengaluru, India.
Introduction: There is growing interest in the use of psychedelic-assisted therapy (PAT) for major depressive disorder (MDD), including treatment-resistant depression. We used randomized controlled trial (RCT) data to compare summary estimates of change in depression ratings with PAT versus comparator treatments in MDD. We also compared response and remission rates, and adverse effects.
View Article and Find Full Text PDFCannabinoids and the male reproductive system: Implications of endocannabinoid signaling pathways.
Maturitas
January 2025
School of Health and Biomedical Sciences, STEM College, RMIT University, Melbourne, Victoria 3000, Australia. Electronic address:
The escalating use and legalization of cannabis (marijuana) in the United States reflect shifting societal attitudes and growing awareness of its potential therapeutic benefits. Historically viewed as a harmful psychoactive substance, contemporary research has shown the intricate pharmacology of cannabis, with its diverse array of cannabinoids and their interactions with the endocannabinoid system. Among these cannabinoids, Δ9-tetrahydrocannabinol is the primary psychoactive component, characterized by its activation of cannabinoid receptors.
View Article and Find Full Text PDFProteomic analysis of psychedelic mushroom isolate and exploring potential antimicrobial peptides against bacteria.
Nat Prod Res
November 2024
Department of Microbiology, Bharathidasan University, Tiruchirappalli, India.
Psychedelic mushrooms belonging to basidiomycota have gained prominence in research due to the range of hallucinogenic compounds. To combat the challenge of antimicrobial resistance, exploring alternative antimicrobial peptides has become crucial. In this study, we present the proteomic analysis of psychedelic mushroom.
View Article and Find Full Text PDFEffects of a Serotonergic Psychedelic on the Lipid Bilayer.
ACS Chem Neurosci
November 2024
Department of Chemical Sciences, Tata Institute of Fundamental Research, Mumbai 400005, India.
Serotonergic psychedelics, known for their hallucinogenic effects, have attracted interest due to their ability to enhance neuronal plasticity and potential therapeutic benefits. Although psychedelic-enhanced neuroplasticity is believed to require activation of 5-hydroxytryptamine (serotonin) 2A receptors (5-HTRs), serotonin itself is less effective in promoting such plasticity. Also, the psychoplastogenic effects of these molecules correlate with their lipophilicity, leading to suggestions that they act by influencing the intracellular receptors.
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