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| http://dx.doi.org/10.4103/joacp.JOACP_564_20 | DOI Listing |
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Potential of traditional medicines in alleviating COVID-19 symptoms.
Front Pharmacol
September 2024
School of Allied Health Sciences, Walailak University, Nakhon Si Thammarat, Thailand.
Article Synopsis
- The review focuses on prevention and treatment strategies for COVID-19, highlighting the role of SARS-CoV-2 mutations in creating variants that evade immunity and some antiviral resistance.
- It identifies 150 natural metabolites and botanical drug-derived bioactive molecules that may offer more effective and less toxic alternatives for COVID-19 treatment, including Thai and Chinese traditional medicine approvals.
- The text emphasizes the impact of long COVID on about 10% of patients and suggests that botanical adjuvants, including vitamin C and E, might help alleviate symptoms and reduce the risk of long COVID progression.
A potential allosteric inhibitor of SARS-CoV-2 main protease (M) identified through metastable state analysis.
Front Mol Biosci
September 2024
Division of Biological and Biomedical Sciences, College of Health and Life Sciences, Hamad Bin Khalifa University, Qatar Foundation, Doha, Qatar.
Anti-COVID19 drugs, such as nirmatrelvir, have been developed targeting the SARS-CoV-2 main protease, M, based on the critical requirement of its proteolytic processing of the viral polyproteins into functional proteins essential for viral replication. However, the emergence of SARS-CoV-2 variants with M mutations has raised the possibility of developing resistance against these drugs, likely due to therapeutic targeting of the M catalytic site. An alternative to these drugs is the development of drugs that target an allosteric site distant from the catalytic site in the protein that may reduce the chance of the emergence of resistant mutants.
View Article and Find Full Text PDFAnti- COVID-19 drug discovery by flavonoid derivatives: an extensive computational drug design approach.
Cell Mol Biol (Noisy-le-grand)
September 2024
Department of Pharmacology, Faculty of Medicine, University Kebangsaan Malaysia, Jalan Yacob Latif, Kuala Lumpur 56000, Malaysia.
The present study deals with the in-silico analyses of several flavonoid derivatives to explore COVID-19 through pharmacophore modelling, molecular docking, molecular dynamics, drug-likeness, and ADME properties. The initial literature study revealed that many flavonoids, including luteolin, quercetin, kaempferol, and baicalin may be useful against SARS β-coronaviruses, prompting the selection of their potential derivatives to investigate their abilities as inhibitors of COVID-19. The findings were streamlined using in silico molecular docking, which revealed promising energy-binding interactions between all flavonoid derivatives and the targeted protein.
View Article and Find Full Text PDFHarnessing traditional Chinese medicine polysaccharides for combatting COVID-19.
Carbohydr Polym
December 2024
Beijing Institute of Pharmacology & Toxicology, Beijing 100850, China; State Key Laboratory of National Security Specially Needed Drug, Beijing Institute of Pharmacology & Toxicology, Beijing 100850, China. Electronic address:
With the global spread of COVID-19 posing ongoing challenges to public health systems, there is an ever-increasing demand for effective therapeutics that can mitigate both viral transmission and disease severity. This review surveys the landscape of polysaccharides derived from traditional Chinese medicine, acclaimed for their medicinal properties and potential to contribute to the COVID-19 response. We specifically focus on the capability of these polysaccharides to thwart SARS-CoV-2 entry into host cells, a pivotal step in the viral life cycle that informs transmission and pathogenicity.
View Article and Find Full Text PDFHow many organic small molecules might be used to treat COVID-19? From natural products to synthetic agents.
Eur J Med Chem
November 2024
Department of Organic Chemistry, College of Chemistry, Jilin University, No.2519 Jiefang Road, Changchun, 130021, People's Republic of China. Electronic address:
Article Synopsis
- The COVID-19 pandemic has spurred significant research into therapeutic drugs targeting SARS-CoV-2, the virus causing the disease.
- This overview discusses organic small molecules derived from natural sources (like plants) and synthetic methods that show potential in treating COVID-19 and related illnesses.
- The development of these molecules, which include natural products and synthetic prodrugs, is believed to contribute to the discovery of multi-targeted treatments for COVID-19 and other viral infections.
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