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Soluble factors in malignant ascites promote the metastatic adhesion of gastric adenocarcinoma cells. | LitMetric

AI Article Synopsis

  • Adenocarcinoma of the proximal stomach is increasingly common in North America, often leading to peritoneal metastasis and malignant ascites, significantly impacting patient survival.
  • Research shows that malignant ascites enhance the adhesion of gastric cancer cells to peritoneal tissues, suggesting a mechanism for the progression of the disease.
  • Targeting specific proteins like MIF and VEGF could offer new therapeutic strategies to prevent or treat peritoneal metastasis in gastric cancer patients.

Article Abstract

Background: Adenocarcinoma of the proximal stomach is the fastest rising malignancy in North America. It is commonly associated with peritoneal accumulation of malignant ascites (MA), a fluid containing cancer and inflammatory cells and soluble proteins. Peritoneal metastasis (PM) is the most common site of gastric cancer (GC) progression after curative-intent surgery and is the leading cause of death among GC patients.

Methods/results: Using a panel of gastric adenocarcinoma cell lines (human: MKN 45, SNU-5; murine: NCC-S1M), we demonstrate that prior incubation of GC cells with MA results in a significant (> 1.7-fold) increase in the number of cells capable of adhering to human peritoneal mesothelial cells (HPMC) (p < 0.05). We then corroborate these findings using an ex vivo PM model and show that MA also significantly enhances the ability of GC cells to adhere to strips of human peritoneum (p < 0.05). Using a multiplex ELISA, we identify MIF and VEGF as consistently elevated across MA samples from GC patients (p < 0.05). We demonstrate that agents that block the effects of MIF or VEGF abrogate the ability of MA to stimulate the adhesion of GC cells to adhere to human peritoneum and promote both ex vivo and in vivo metastases.

Conclusion: Agents targeting MIF or VEGF may be relevant to the treatment or prevention of PM in GC patients.

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Source
http://dx.doi.org/10.1007/s10120-022-01338-1DOI Listing

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