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| http://dx.doi.org/10.1016/S0140-6736(22)01530-6 | DOI Listing |
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Protocol for the systematic review of age and sex in preclinical models of age-correlated diseases.
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German Centre for the Protection of Laboratory Animals (Bf3R), German Federal Institute for Risk Assessment (BfR), Berlin, Berlin, Germany.
The translation of animal-based biomedical research into clinical research is often inadequate. Maximizing translation should be central to animal research on human diseases, guiding researchers in study design and animal model selection. However, practical considerations often drive the choice of animal model, which may not always reflect key patient characteristics, such as sex and age, impacting the disease's course.
View Article and Find Full Text PDFLong-term health outcomes and quality of life in women with untreated pelvic floor dysfunction: a single-center cohort study.
Front Public Health
January 2025
Department of Colorectal Surgery, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People's Hospital, Quzhou, Zhejiang, China.
Objective: This study aimed to evaluate the long-term health outcomes and quality of life (HRQoL) associated with untreated pelvic floor dysfunction (PFD) in women, and to identify key factors contributing to symptom severity.
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Higher triglyceride-glucose index and triglyceride glucose-body mass index protect against sarcopenia in Chinese middle-aged and older non-diabetic women: a cross-sectional study.
Front Public Health
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Department of Radiology, Hebei Medical University Third Hospital, Shijiazhuang, Hebei, China.
Purpose: Sarcopenia, an age-related complication, constitutes a major public health problem given the aging of the population. However, it is frequently overlooked and undertreated in mainstream practice. The study aimed to investigate the correlations between triglyceride-glucose (TyG) index and TyG-body mass index (BMI) and sarcopenia in non-diabetic middle-aged and older women and whether they would be helpful indicators of sarcopenia.
View Article and Find Full Text PDFBackground: Home health agencies (HHAs) provide vital community-based services for older adults. Under-resourced HHAs that are disconnected from broader community emergency planning efforts may struggle to maintain services during emergencies. As climate-related disasters become more prevalent, HHA services are increasingly at risk, and policymakers have focused on the services they provide to older adults.
View Article and Find Full Text PDFEstimating financial and health burden by initial Medicare plan choice and history of cancer.
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Department of Health Policy, Vanderbilt University School of Medicine, Nashville, TN 37203, United States.
Understanding the downstream consequences of initial Medicare plan selection is necessary to ensure access to and affordability of health care services, especially for older adults with serious illness. We used 2008-2020 data from the Health and Retirement Study to estimate financial and health burden by initial Medicare plan selection (traditional Medicare without supplemental coverage, traditional Medicare plus supplemental coverage, or Medicare Advantage) and self-reported history of cancer. Initially choosing benefits with greater financial protections (either traditional Medicare plus supplemental coverage or Medicare Advantage) relative to traditional Medicare without supplemental coverage was associated with lower levels of out-of-pocket spending and a lower likelihood of reporting cost-related medication nonadherence and fair or poor health.
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