Sepsis is a life-threatening organ dysfunction. An animal model mimicking sepsis utilizes lipopolysaccharide (LPS), an endotoxin recognized as the most potent bacterial mediator of sepsis. Melatonin (MLT), an effective anti-inflammatory and antioxidant agent, is a promising adjunctive drug for sepsis. This study aimed to estimate the potential of MLT in preventing LPS-induced liver damage in Wistar rats by determining the levels of serum and tissue biochemical markers that reflect liver state and function, i.e., serum levels of transaminases and albumin, as well as a panel of oxidative stress-related biomarkers. Additionally, a pathohistological analysis of liver tissue was conducted. Pre-treatment with MLT prevented an LPS-induced increase in serum and tissue liver damage markers and a decrease in the tissue antioxidant capacity, in both enzymatic and non-enzymatic systems. Micromorphological liver tissue changes mirrored the alterations observed in the biochemical status. In rats with LPS-induced sepsis, melatonin was shown to be a crucial antioxidant and anti-inflammatory agent, with vital roles in the alleviation of oxidative stress, causing an increase of the antioxidant capacities and the improvement of the liver's microscopic appearance.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.tice.2022.101904 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Ramelteon exposure and survival of critically Ill sepsis patients: a retrospective study from MIMIC-IV.
BMC Anesthesiol
December 2024
Department of Anesthesiology, Guangdong Provincial Key Laboratory of Precision Anaesthesia and Perioperative Organ Protection, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, Guangdong, China.
Background: The effect of ramelteon, a melatonin receptor agonist, on survival in septic patients remains unknown. The purpose of this retrospective cohort study was to explore the relationship between ramelteon exposure and survival outcomes in septic patients.
Methods: Data from septic patients admitted to the intensive care unit (ICU) were extracted from the Medical Information Mart for Intensive Care IV (MIMIC-IV) database, with patients categorized into ramelteon exposure and non-exposure groups based on the use of ramelteon.
Investigation of the effects of melatonin on lung tissue through the NLRP3/TLR2/NEK7 pathway in an experimental endotoxemia model.
Cell Mol Biol (Noisy-le-grand)
November 2024
Yozgat Bozok University, Faculty of Medicine, Department of Anatomy, Yozgat, Turkey.
Article Synopsis
- - Sepsis is a serious condition characterized by inflammation and cell death, often leading to multiple organ failure, requiring quick medical attention; lipopolysaccharide (LPS) triggers inflammatory responses through specific receptors like TLR-2.
- - The study explores the role of melatonin (MEL) in reducing lung injury caused by LPS-induced septic shock in rats, highlighting its potential to lower the expressions of inflammatory markers NEK7, TLR2, and NLRP3.
- - Results showed that melatonin treatment reduced lung tissue damage, cell infiltration, and wall thickening, indicating that it may provide therapeutic benefits in managing sepsis-related acute lung injury.
Melatonin attenuates sepsis-induced muscle atrophy by regulating the PI3K/Akt signaling pathway.
Int Immunopharmacol
January 2025
Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang 330006, China; Jiangxi Provincial Key Laboratory of Respiratory Diseases, Jiangxi Institute of Respiratory Diseases, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang 330006, China. Electronic address:
Background: In intensive care units, sepsis-related muscle atrophy is a severe complication of numerous diseases, yet the underlying mechanism and potential therapeutic options remain elusive. Recent research has identified melatonin as a promising candidate for attenuating organ dysfunction triggered by sepsis.
Methods: We used in vitro and in vivo models to simulate sepsis, C2C12 myotubes were treated with LPS, and the mice underwent cecal ligation and puncture (CLP) surgery.
The impact of skin-to-skin contact upon stress in preterm infants in a neonatal intensive care unit.
Front Pediatr
November 2024
Department of Pediatrics No2, I. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine.
Introduction: Neonatal stress significantly affects the early adaptation, maturation and long-term development of preterm infants.
The Objective Of The Study: To investigate the effect of skin-to-skin contact (SSC) on stress level in preterm infants.
Materials And Methods: The research was a prospective study.
Melatonin Mediates Cardiac Tissue Damage under Septic Conditions Induced by Lipopolysaccharide.
Int J Mol Sci
October 2024
Institute for Biochemistry, Faculty of Medicine, University of Niš, 18000 Niš, Serbia.
Lipopolysaccharide (LPS) is known to induce oxidative stress and inflammation, leading to significant damage in cardiac tissues. This study investigates the protective effects of melatonin (MLT) against LPS-induced oxidative damage, inflammation, and apoptosis in rat heart tissue. Rats were divided into four groups ( = 6 per group): control, melatonin-treated, LPS-treated, and LPS + melatonin-treated.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!