In this research, the influences of cryogenically treated stainless steel grade 317 on the eco-friendly near-dry wire-cut electrical discharge machining (NDWEDM) processes have been investigated using the minimum quantity of water mixed with oxygen gas (oxygen mist) dielectric fluid. The stainless steel grade 317 has been applied to make the various biomedical and industrial components due to its high creep strength. The wire wear ratio (WWR) and cutting rate (CR) of NDWEDM are compared using cryogenically treated and untreated work materials by Taguchi's analysis. The water flow rate, gas pressure, spark current, and pulse width had been considered as process parameters. The microstructure of wire electrode and machined surfaces of treated/untreated materials had been compared by scanning electron microscope (SEM) images. The WWR and CR of cryogenically treated materials in NDWEDM are 20.31% lower and 22.32% higher than untreated materials, respectively.
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http://dx.doi.org/10.1007/s11356-022-22843-x | DOI Listing |
World J Radiol
January 2025
Department of Radiology, The Ohio State University Medical Center, Columbus, OH 43210, United States.
Solid organ tumors present a significant healthcare challenge, both economically and logistically, due to their high incidence and treatment complexity. In 2023, out of the 1.9 million new cancer cases in the United States, over 73% were solid organ tumors.
View Article and Find Full Text PDFJ Colloid Interface Sci
January 2025
The Department of Medical Imaging, Guangzhou Key Laboratory of Molecular Functional Imaging and Artificial Intelligence for Major Brain Diseases, The Affiliated Guangdong Second Provincial General Hospital of Jinan University, Jinan University, Guangzhou 518037 China. Electronic address:
Microwave dynamic therapy (MWDT) destroy tumor cells using reactive oxygen species (ROS), but its effectiveness is limited by low ROS production and intracellular oxygen (O) availability. This study presents a novel strategy using manganese (II) ion (Mn) doped iron (Fe)-based metal-organic framework (Fe MOF) nanoparticles (NPs) to enhance both O generation and ROS production for improved MWDT. Incorporating Mn into Fe MOF narrows the bandgap from 0.
View Article and Find Full Text PDFSci Rep
January 2025
Center for Automation and Robotics, CSIC-Universidad Politécnica de Madrid, Arganda del Rey, Madrid, 28500, Spain.
Aluminium and its alloys, especially Al6061, have gathered significant interest among researchers due to its less density, great durability, and high strength. Due to their lightweight properties, the precise machining of these alloys can become expensive through conventional machining operations for intricate products. Therefore, non-traditional machining such as electric discharge machining (EDM) can potentially be opted for the cutting of Al6061.
View Article and Find Full Text PDFNat Struct Mol Biol
January 2025
Department of Biochemistry, Duke University School of Medicine, Durham, NC, USA.
Transient receptor potential channel subfamily M member 3 (TRPM3) is a Ca-permeable cation channel activated by the neurosteroid pregnenolone sulfate (PregS) or heat, serving as a nociceptor in the peripheral sensory system. Recent discoveries of autosomal dominant neurodevelopmental disorders caused by gain-of-function mutations in TRPM3 highlight its role in the central nervous system. Notably, the TRPM3 inhibitor primidone, an anticonvulsant, has proven effective in treating patients with TRPM3-linked neurological disorders and in mouse models of thermal nociception.
View Article and Find Full Text PDFACS Appl Mater Interfaces
January 2025
Key Laboratory of Cryogenics Science and Technology, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Laboratory of Controllable Preparation and Application of Nanomaterials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
Sublethal tumor cells have an urgent need for energy, making it common for them to switch metabolic phenotypes between glycolysis and oxidative phosphorylation (OXPHOS) for compensatory energy supply; thus, the synchronous interference of dual metabolic pathways for limiting energy level is essential in inhibiting sublethal tumor growth. Herein, a multifunctional nanoplatform of Co-MOF-loaded anethole trithione (ADT) and myristyl alcohol (MA), modified with GOx and hyaluronic acid (HA) was developed, namely, CAMGH. It could synchronously interfere with dual metabolic pathways including glycolysis and OXPHOS to restrict the adenosine triphosphate (ATP) supply, achieving the inhibition to sublethal tumors after microwave (MW) thermal therapy.
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