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Hygrometry behavior during high-flow nasal oxygen therapy and non-invasive mechanical ventilation: A narrative review of bench to clinical studies.
J Intensive Med
October 2024
Intensive Care Unit, Hospital Morales Meseguer, Murcia, Spain.
Recently, there has been growing interest in knowing the best hygrometry level during high-flow nasal oxygen and non-invasive ventilation (NIV) and its potential influence on the outcome. Various studies have shown that breathing cold and dry air results in excessive water loss by nasal mucosa, reduced mucociliary clearance, increased airway resistance, reduced epithelial cell function, increased inflammation, sloughing of tracheal epithelium, and submucosal inflammation. With the Coronavirus Disease 2019 pandemic, using high-flow nasal oxygen with a heated humidifier has become an emerging form of non-invasive support among clinicians.
View Article and Find Full Text PDFA Case of Thermal Burns of the Larynx in a Toddler.
Cureus
December 2024
Otolaryngology, Head and Neck Surgery, Ehime University Graduate School of Medicine, Toon, JPN.
Thermal burns of the larynx are uncommon but can lead to serious upper airway obstruction due to edema and bleeding, especially in children who may struggle to communicate their symptoms effectively. This report presents the case of a one-year-and-seven-month-old boy who developed stridor and respiratory distress after eating a heated potato, which ultimately required tracheal intubation. The initial evaluation suggested foreign body aspiration; however, laryngoscopy confirmed significant arytenoid swelling and airway narrowing due to thermal burns.
View Article and Find Full Text PDFAirway organoids: 3D toxicology evaluation models in vitro of heated tobacco products for health risk.
Toxicol In Vitro
December 2024
China National Tobacco Quality Supervision and Test Center, Zhengzhou 450001, China; Beijing Life Science Academy, Beijing 102209, China; Key Laboratory of Tobacco Biological Effects, Zhengzhou 450001, China.
Cigarette smoking poses significant health risks, particularly to the airway, which consists predominantly of basal, club, and ciliated cells that are highly susceptible to damage from exogenous stimuli. Traditional in vitro toxicology relies on 2D cell cultures, which lack the structural complexity and functional relevance of airway architecture. As a novel category of tobacco products, the health implications of heated tobacco products (HTPs) remain largely unknown.
View Article and Find Full Text PDFComparison of Inspiration-Synchronized and Continuous Vibrating Mesh Nebulizer During Adult Invasive Mechanical Ventilation.
J Aerosol Med Pulm Drug Deliv
December 2024
Department of Cardiopulmonary Sciences, Division of Respiratory Care, Rush University, Chicago, Illinois, USA.
Aerosol delivery may be enhanced by utilizing an inspiration-synchronized nebulization mode, where nebulization occurs only during inspiration. This study aimed to compare aerosol delivery of albuterol via a prototype of an inspiration-synchronized vibrating mesh nebulizer (VMN) versus continuous VMN during invasive mechanical ventilation. A critical care ventilator equipped with a heated-wire circuit to deliver adult parameters was attached to an endotracheal tube (ETT), a collection filter, and a test lung.
View Article and Find Full Text PDFInternal Temperature of Neonatal Endotracheal Tube Predicted by Infrared Thermography: A Neonatal Bench Study.
Pediatr Pulmonol
November 2024
Department of Community Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Introduction: Neonatal ventilators are managed by monitoring the inspiratory gas temperature with a probe placed outside the incubator, although the temperature decreases as the gases passe through the ventilator circuit extension tube and endotracheal tube (ETT). There are no established methods for measuring the internal temperature of the ETT. This bench study aimed to investigate the feasibility of using infrared thermography (IRT) to predict the internal temperature of the ETT.
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