AI Article Synopsis
- Ischemic stroke is a common condition in adults that can lead to significant neurological impairments due to the loss of neurons.
- Current treatment strategies focus on either reducing neuron death in affected areas or replacing lost cells, with stem cell therapy emerging as a leading method for promoting brain repair.
- This review highlights the role of endogenous neural stem cells in neurogenesis post-stroke and aims to guide future therapeutic strategies for ischemic stroke and other neurological issues.
Article Abstract
Ischemic stroke is a very common cerebrovascular accident that occurred in adults and causes higher risk of neural deficits. After ischemic stroke, patients are often left with severe neurological deficits. Therapeutic strategies for ischemic stroke might mitigate neuronal loss due to delayed neural cell death in the penumbra or seek to replace dead neural cells in the ischemic core. Currently, stem cell therapy is the most promising approach for inducing neurogenesis for neural repair after ischemic stroke. Stem cell treatments include transplantation of exogenous stem cells but also stimulating endogenous neural stem cells (NSCs) proliferation and differentiation into neural cells. In this review, we will discuss endogenous NSCs-induced neurogenesis after ischemic stroke and provide perspectives for the therapeutic effects of endogenous NSCs in ischemic stroke. Our review would inform future therapeutic development not only for patients with ischemic stroke but also with other neurological deficits.
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| http://dx.doi.org/10.1007/s12975-022-01078-5 | DOI Listing |
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