Human-mouse chimeras offer advantages for studying the pathophysiology of human cells in vivo. Chimeric mouse brains have been created by engrafting human fetal tissue- or pluripotent stem cell-derived progenitor cells into the neonatal mouse brain. This provides new opportunities to understand human brain development and neurological disorders.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9440171 | PMC |
| http://dx.doi.org/10.1186/s13619-022-00135-6 | DOI Listing |
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