The Warburg effect: Saturation of mitochondrial NADH shuttles triggers aerobic lactate fermentation.

Mol Cell

Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI 48824, USA; Department of Chemical Engineering and Materials Science, Michigan State University, East Lansing, MI 48824, USA. Electronic address:

Published: September 2022

In this issue of Molecular Cell, Wang et al. investigate the Warburg effect in proliferating cells and demonstrate that lactate fermentation is a secondary mechanism activated after mitochondrial shuttles exceed their capacity to oxidize cytosolic NADH.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9888598PMC
http://dx.doi.org/10.1016/j.molcel.2022.08.004DOI Listing

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