A useful 1,3-, reagent (ClNHCHSiMeCHCl) and its (4 + 2) annulation with propynones have been developed. The (4 + 2) annulation is promoted by NaHCO an intermolecular -1,4-addition/intramolecular alkylation process, leading to 1,3-azasilinones in good yields. Diverse functionalization of the alkene, carbonyl, and nitrogen moieties on the 1,3-azasilinone has been demonstrated, showcasing the potential of the approach in the synthesis of bioactive molecules containing silaazacycles.
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| http://dx.doi.org/10.1021/acs.orglett.2c02665 | DOI Listing |
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