AI Article Synopsis
- The study investigates risk factors for early vestibular dysfunction in patients with congenital cytomegalovirus (cCMV) and its impact on motor development.
- Patients with hearing loss at birth have six times the risk of developing vestibular issues, and additional predictors include hearing impairment and presence of periventricular cysts.
- Early vestibular loss significantly negatively affects motor skills, suggesting that hearing and imaging assessments could improve targeted vestibular evaluations in cCMV patients.
Article Abstract
Objectives: Congenital cytomegalovirus (cCMV) can affect vestibular function, which is an important cornerstone for early motor development. This study aims to identify risk factors for early vestibular dysfunction with severe repercussions on the motor outcome.
Methods: This prospective cohort study included 169 cCMV-patients with complete vestibular assessment (lateral video Head Impulse Test and cervical Vestibular Evoked Myogenic Potentials) before the age of 18 months (mean 8.9, standard deviation 3.27 months). Motor results using the Alberta Infant Motor Scale were collected in 152 of these patients. Logistic and linear regression models were applied to identify risk factors for the vestibular and motor outcomes, respectively.
Results: The odds of developing early vestibular dysfunction were 6 times higher in patients presenting with hearing loss at birth compared to those born with normal hearing (p = .002). Within the latter group, significant predictors for vestibular dysfunction were (delayed-onset) hearing impairment at the time of vestibular testing (p = .003) and the presence of periventricular cysts on magnetic resonance imaging (p = .005). Remarkably, none of the patients infected during the third trimester of pregnancy (n = 14) developed early vestibular dysfunction. On average, vestibular-impaired patients had a z-score on the Alberta Infant Motor Scale that was 1.17 points lower than patients without vestibular deficit (p < .001).
Conclusion: Early vestibular loss can have a significant adverse effect on motor development. Hearing and cranial imaging findings could facilitate the widespread implementation of a (targeted) vestibular assessment approach in the cCMV-population.
Level Of Evidence: 3 Laryngoscope, 133:1757-1765, 2023.
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| http://dx.doi.org/10.1002/lary.30375 | DOI Listing |
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