AI Article Synopsis
- - The text discusses the significance of spiro[azetidine-indolines] as key structures in various bioactive compounds.
- - It highlights the current limitations in synthesizing a specific type of spiro[azetidine-indolines] and the unexplored area of chiral spiro[azetidine-3,3'-indolines].
- - The work introduces a novel copper(I)-catalyzed reaction that enables an efficient and selective synthesis of chiral spiro[azetidine-3,3'-indoline]-2,2'-diones, marking a breakthrough in this area of research.
Article Abstract
Spiro[azetidine-indolines] are important scaffolds in diverse bioactive compounds. Current efforts to synthesize spiro[azetidine-indolines] are limited to chiral spiro[azetidine-2,3'-indolines]. Asymmetric synthesis of structurally similar chiral spiro[azetidine-3,3'-indolines] remains unexplored. In this work, the first copper(I)-catalyzed asymmetric Kinugasa/aryl C-C coupling cascade reaction is described. This provides a straightforward access to densely functionalized chiral spiro[azetidine-3,3'-indoline]-2,2'-diones in good yields and with high enantioselectivity.
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| http://dx.doi.org/10.1002/anie.202208323 | DOI Listing |
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