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Preclinical and First-in-Human Study of a Compact Radionuclide Labeled Self-Assembly Nanomedicine for Chemo-Radio-Theranostics of Cancer.
ACS Nano
January 2025
Department of Diagnostic Radiology, Yong Loo Lin School of Medicine, National University of Singapore, 119074, Singapore.
The emerging combination of chemotherapy and radionuclide therapy has been actively investigated to overcome the limitations of monotherapy and augment therapeutic efficacy. However, it remains a challenge to design a single delivery vehicle that can incorporate chemotherapeutics and radionuclides into a compact structure. Here, a chelator DOTA- or NOTA-modified Evans blue conjugated camptothecin molecule (EB-CPT) nanoprodrug was synthesized, which could self-assemble into nanoparticles due to its inherent amphiphilicity.
View Article and Find Full Text PDFFluorescence tunable carbon dots for nuclear dynamics and gastrointestinal imaging in live zebrafish and their toxicity evaluation by cardio-craniofacial disfunction assessment.
Nanoscale
January 2025
Chemistry Division, Bhabha Atomic Research Centre, Trombay, Mumbai-400085, India.
Sub-cellular organelle anomalies are frequently observed in diseases such as cancer. Early and precise diagnosis of these alterations can be crucial for patient outcomes. However, current diagnostic tools using conventional organic dyes or metal quantum dots face limitations, including poor biocompatibility, stringent storage conditions, limited solubility in aqueous media, and slow staining speeds.
View Article and Find Full Text PDFDrug carrier-assisted combined chemo- and radionuclide therapy for tumors of diverse origins: effects of therapeutic schemes on tumor responses.
Biomater Sci
January 2025
Institute of Biomedical Systems and Biotechnology, Peter the Great Saint Petersburg Polytechnic University, St Petersburg, 194064, Russia.
Despite the promising results in cancer treatment, standard monotherapy remains insufficient for a wide range of oncological diseases. Combined therapy can significantly improve therapeutic outcomes compared to single-agent treatments. However, identifying the optimal treatment regimen for combined therapy can be a challenging task.
View Article and Find Full Text PDFSimultaneous radionuclide determination using PSresin: 2in2 and 2in1 tandem configuration.
Anal Chim Acta
February 2025
Departament d'Enginyeria Química i Química Analítica, Universitat de Barcelona, Marti i Franqués, 1-11, ES-08028, Barcelona, Spain; Serra-Húnter Programme, Generalitat de Catalunya, Barcelona, Spain; Institut de Recerca de l'Aigua, University of Barcelona, Spain. Electronic address:
Background: Analyzing mixtures of radionuclides is a complex task. Two situations are the mixtures of Sr with Sr and Sr with plutonium isotopes. The challenge arises in emergency scenarios resulting from accidents where the activity of Sr is over 20 times higher than that of Sr, complicating its quantification and requiring delayed measurements.
View Article and Find Full Text PDFVisible light-responsive enrofloxacin PEC aptasensor based on CN QDs sensitized BiOBr nanosheets.
Anal Chim Acta
February 2025
School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang, 212013, PR China; Key Laboratory of Optic-Electric Sensing and Analytical Chemistry for Life Science, MOE, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao, 266042, PR China. Electronic address:
Background: The excessive application of enrofloxacin (ENR) results in residues contaminating both food and the environment. Consequently, developing robust analytical methods for the selective detection of ENR is crucial. The photoelectrochemical (PEC) sensor has emerged as a highly sensitive analytical technique that has seen rapid development in recent years.
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